Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers.
BRCA1/2
DNA damage response
DNA damage tolerance
DNA replication
PARP inhibitors
chemotherapy
drug resistance
replication fork
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
02
2020
accepted:
09
04
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g., due to inactivating mutations in
Identifiants
pubmed: 32432041
doi: 10.3389/fonc.2020.00670
pmc: PMC7214843
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
670Informations de copyright
Copyright © 2020 Liptay, Barbosa and Rottenberg.
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