Aged Tendon Stem/Progenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits.
3D cell sheet model
tendon age-related degeneration
tendon regeneration
tendon stem/progenitor cells
tenogenesis
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
12
2019
accepted:
09
04
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Tendons are dense connective tissues, which are critical for the integrity and function of our musculoskeletal system. During tendon aging and degeneration, tendon stem/progenitor cells (TSPCs) experience profound phenotypic changes with declined cellular functions that can be linked to the known increase in complications during tendon healing process in elderly patients. Tissue engineering is a promising approach for achieving a complete recovery of injured tendons. However, use of autologous cells from aged individuals would require restoring the cellular fitness prior to implantation. In this study, we applied an established cell sheet model for
Identifiants
pubmed: 32432103
doi: 10.3389/fbioe.2020.00406
pmc: PMC7214752
doi:
Types de publication
Journal Article
Langues
eng
Pagination
406Informations de copyright
Copyright © 2020 Yan, Yin, Brochhausen, Pfeifer, Alt and Docheva.
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