The pharmacological development of direct acting agents for emerging needed therapy against severe acute respiratory syndrome coronavirus-2.
Active Transport, Cell Nucleus
/ drug effects
Antibodies, Monoclonal
/ therapeutic use
Antiviral Agents
/ therapeutic use
Betacoronavirus
/ genetics
COVID-19
Coronavirus Infections
/ drug therapy
Drug Development
Genome, Viral
Humans
Killer Cells, Natural
/ immunology
Pandemics
Pneumonia, Viral
/ drug therapy
SARS-CoV-2
COVID-19 Drug Treatment
Journal
Journal of the Chinese Medical Association : JCMA
ISSN: 1728-7731
Titre abrégé: J Chin Med Assoc
Pays: Netherlands
ID NLM: 101174817
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
21
5
2020
medline:
1
9
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
Recently, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was quickly identified as the causal pathogen leading to the outbreak of SARS-like illness all over the world. As the SARS-CoV-2 infection pandemic proceeds, many efforts are being dedicated to the development of diverse treatment strategies. Increasing evidence showed potential therapeutic agents directly acting against SARS-CoV-2 virus, such as interferon, RNA-dependent RNA polymerase inhibitors, protease inhibitors, viral entry blockers, neuraminidase inhibitor, vaccine, antibody agent targeting the SARS-CoV-2 RNA genome, natural killer cells, and nucleocytoplasmic trafficking inhibitor. To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy. This article reviews the current and future development of direct acting agents against SARS-CoV-2.
Identifiants
pubmed: 32433345
doi: 10.1097/JCMA.0000000000000353
pmc: PMC7493775
pii: 02118582-202008000-00009
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
712-718Références
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