Efficacy of Sedation by Midazolam in Association With Meperidine or Fentanyl and Role of Patient Distress During Elective Colonoscopy.


Journal

Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
ISSN: 1538-9766
Titre abrégé: Gastroenterol Nurs
Pays: United States
ID NLM: 8915377

Informations de publication

Date de publication:
Historique:
pubmed: 21 5 2020
medline: 30 4 2021
entrez: 21 5 2020
Statut: ppublish

Résumé

Meperidine and fentanyl are opioids currently used in addition to midazolam for sedation and analgesia during colonoscopy in Italy. The aim of the study was to assess the impact of patients' psychological state before elective colonoscopy on the efficacy of the sedation regimens. Eighty outpatients who underwent an elective colonoscopy were included in our study. The Hospital Anxiety and Depression Scale questionnaire was self-administered to evaluate basal anxiety and depression state. The rate of baseline discomfort was evaluated by a standard 100-mm visual analog scale. Sedation was obtained alternatively with a midazolam-meperidine or midazolam-fentanyl combination. There were no statistically significant differences between the fentanyl and meperidine groups on body mass index, age, and gender composition. Patients in the meperidine group reported less pain during colonoscopy than patients in the fentanyl group. There were statistically significant positive correlations in the meperidine group with the distress, anxiety, and depression. Our study has pointed out greater effectiveness of the midazolam plus meperidine regimen, equal recovery times, and no significant differences in the duration of the endoscopic examinations. The evaluation of patients' psychological status seems to predict the efficacy of sedation when the nociceptive component of pain is well controlled.

Identifiants

pubmed: 32433429
doi: 10.1097/SGA.0000000000000456
pii: 00001610-202005000-00007
doi:

Substances chimiques

Analgesics, Opioid 0
Hypnotics and Sedatives 0
Meperidine 9E338QE28F
Midazolam R60L0SM5BC
Fentanyl UF599785JZ

Types de publication

Journal Article

Langues

eng

Pagination

258-263

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Auteurs

Stefano Pontone (S)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Rossella Palma (R)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Giuseppe Donato (G)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Raffaele Borghini (R)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Stefano Frattaroli (S)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Marilena Raniolo (M)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Cristina Panetta (C)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

Marco Lauriola (M)

Stefano Pontone, PhD, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Rossella Palma, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Giuseppe Donato, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Raffaele Borghini, MD, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Stefano Frattaroli, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marilena Raniolo, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Cristina Panetta, MD, Department of Surgical Sciences, Sapienza University, Rome, Italy.
Marco Lauriola, Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.

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