Pivotal role of CD103 in the development of psoriasiform dermatitis.
Animals
Antigens, CD
/ genetics
Autoimmunity
/ genetics
Cell Differentiation
/ genetics
Dermatitis
/ genetics
Female
Flow Cytometry
Immunohistochemistry
Integrin alpha Chains
/ genetics
Keratinocytes
/ metabolism
Langerhans Cells
/ metabolism
Male
Mice, Inbred C57BL
Psoriasis
/ genetics
Reverse Transcriptase Polymerase Chain Reaction
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 05 2020
20 05 2020
Historique:
received:
25
09
2019
accepted:
30
04
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs). CD103 has been originally implicated in the attachment of lymphocytes to epithelium in the gut and skin through the interaction with E-cadherin expressed on intestinal epithelial cells, keratinocytes, and Langerhans cells (LCs). However, an impact of CD103 on the cutaneous immune responses and the development of inflammatory skin diseases remains elusive. Here, we report that CD103 regulates the development of psoriasiform dermatitis through the control of the function of cDCs. Deficiency in CD103 exacerbates psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes. Furthermore, deficiency in CD103 not only accelerates the production of proinflammatory cytokines in psoriatic lesions but also promotes the generation of lymphocytes producing interleukin (IL)-17 in the skin-draining peripheral lymph nodes (PLNs). Under the deficiency in CD103, cDCs localized in PLNs enhance cytokine production following activation. Thus, our findings reveal a pivotal role for CD103 in the control of the function of cDCs to regulate cutaneous inflammation in psoriasiform dermatitis.
Identifiants
pubmed: 32433498
doi: 10.1038/s41598-020-65355-9
pii: 10.1038/s41598-020-65355-9
pmc: PMC7239860
doi:
Substances chimiques
Antigens, CD
0
Integrin alpha Chains
0
alpha E integrins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8371Commentaires et corrections
Type : ErratumIn
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