Squash cytology of a case of medulloblastoma with myogenic differentiation.
medulloblastoma
medulloblastoma with myogenic differentiation
squash cytology
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
27
03
2020
revised:
30
04
2020
accepted:
07
05
2020
pubmed:
21
5
2020
medline:
15
10
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Medulloblastoma with myogenic differentiation is not a distinct entity but a pattern of differentiation seen in <1% of medulloblastomas. Although squash cytology of medulloblastoma is well described, there are no reports available describing squash cytomorphology of this unusual variant of medulloblastoma. Intraoperative squash smears on a 2-year-old girl with a midline posterior fossa space occupying lesion revealed features of an embryonal tumor composed of small, round, and blue cells. In addition, it had several large, round, eosinophilic rhabomyoblasts, and a few strap cells scattered among the sea of small blue cells. Subsequent histology showed features of a medulloblastoma, classic type with myogenic differentiation. Molecular subtyping, based on immunohistochemistry alone, was in keeping with a non-Wnt/non-SHH activated type. Here we describe the squash cytomorphological details of a case of medulloblastoma with myogenic differentiation, along with its cytological differentials.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1121-1124Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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