G-Protein-Coupled Receptor SRBC-48 Protects against Dendrite Degeneration and Reduced Longevity Due to Infection.

Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism Dendrites / metabolism Longevity Pseudomonas Infections / metabolism Pseudomonas aeruginosa Receptors, G-Protein-Coupled / metabolism
Caenorhabditis elegans DAF-16 G-protein-coupled receptor Pseudomonas aeruginosa SRBC-48 infection inflammation longevity neurodegeneration pathogens

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
19 05 2020
Historique:
received: 21 10 2019
revised: 06 03 2020
accepted: 28 04 2020
entrez: 21 5 2020
pubmed: 21 5 2020
medline: 22 5 2021
Statut: ppublish

Résumé

Increasing evidence suggests that deficient immune modulation and microbial infections underline neurodegeneration, but the mechanisms remain obscure. Here, we show that the G-protein-coupled receptor (GPCR) SRBC-48, which belongs to the class BC serpentine receptors, has a protective role in Caenorhabditis elegans dendrite degeneration caused by Pseudomonas aeruginosa infection. Our results indicate that SRBC-48 functions in a cell-autonomous manner in AWC neurons to protect against infection-associated dendrite degeneration. The absence of SRBC-48 results in a reduced lifespan caused by a pathogen infection early in life that induces dendrite degeneration. The decreased longevity in animals deficient in SRBC-48 is due to uncontrolled activation of immune genes, particularly those regulated by the FOXO family transcription factor DAF-16 that is part of the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2. These results reveal how an infection early in life can not only induce dendrite degeneration but also reduce lifespan.

Identifiants

DOI: 10.1016/j.celrep.2020.107662 PMID: 32433971 PMC: PMC7304231
pubmed: 32433971
pii: S2211-1247(20)30615-X
doi: 10.1016/j.celrep.2020.107662
pmc: PMC7304231
mid: NIHMS1596753
pii:
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

107662

Subventions

Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI117911
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM070977
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM070977
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Supender Kaur (S)

Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.

Alejandro Aballay (A)

Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: aballay@ohsu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Cellules › Neurones › Dendrites › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Pseudomonas › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › G-Protein-Coupled Receptor SRBC-48 Protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › G-Protein-Coupled Receptor SRBC-48 Protects...