Radiofrequency irradiation attenuates angiogenesis and inflammation in UVB-induced rosacea in mouse skin.
Animals
Cell Movement
/ radiation effects
Cell Proliferation
/ radiation effects
Disease Models, Animal
Endothelial Cells
Epidermis
Gene Expression
/ radiation effects
Humans
Interleukin-1beta
/ genetics
Keratinocytes
Male
Mice
Neovascularization, Pathologic
/ metabolism
RNA, Messenger
/ metabolism
Radio Waves
Radiofrequency Therapy
Rosacea
/ metabolism
Signal Transduction
/ radiation effects
Ultraviolet Rays
Vascular Endothelial Growth Factor A
/ genetics
Vascular Endothelial Growth Factor Receptor-2
/ genetics
VEGF
angiogenesis
microneedling radiofrequency
rosacea
ultraviolet B (UVB)
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
revised:
09
05
2020
received:
04
10
2019
accepted:
14
05
2020
pubmed:
21
5
2020
medline:
16
2
2022
entrez:
21
5
2020
Statut:
ppublish
Résumé
Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially keratinocyte-related VEGF, a potent angiogenic factor. The upregulations of VEGF expression and its secretion promote the formation of new blood vessels and exacerbates rosacea. In this study, radiofrequency (RF) irradiation reduced keratinocyte proliferation in the epidermal layer, the expressions of pro-inflammatory cytokines, angiogenesis-related inflammatory factors and VEGF in our UVB-induced model of rosacea in vitro and in vivo. RF irradiation attenuated VEGF-induced angiogenesis-associated processes such as tube formation, cell migration and endothelial cell proliferation. Notably, blood vessel densities in the skins of UVB-treated mice and rosacea patients were significantly decreased by RF irradiation. These results provide experimental and molecular evidence regarding the effectiveness of RF irradiation for the treatment of rosacea.
Substances chimiques
IL1B protein, mouse
0
Interleukin-1beta
0
RNA, Messenger
0
Vascular Endothelial Growth Factor A
0
vascular endothelial growth factor A, mouse
0
Kdr protein, mouse
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-666Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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