A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1.

Animals Malaria / prevention & control Malaria Vaccines Malaria, Falciparum / prevention & control Mice Plasmodium falciparum Sporozoites Vaccines, Attenuated

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
20 05 2020
Historique:
received: 19 09 2019
accepted: 22 04 2020
entrez: 22 5 2020
pubmed: 22 5 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Immunization with attenuated

Identifiants

DOI: 10.1126/scitranslmed.aaz5629 PMID: 32434847
pubmed: 32434847
pii: 12/544/eaaz5629
doi: 10.1126/scitranslmed.aaz5629
pii:
doi:

Substances chimiques

Malaria Vaccines 0
Vaccines, Attenuated 0

Types de publication

Clinical Trial, Phase I Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R44 AI069631
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Meta Roestenberg (M)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
ORCID: 0000-0002-5052-2830

Jona Walk (J)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
ORCID: 0000-0002-9420-4578

Saskia C van der Boor (SC)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Marijke C C Langenberg (MCC)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Marie-Astrid Hoogerwerf (MA)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
ORCID: 0000-0002-3088-3380

Jacqueline J Janse (JJ)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Mikhael Manurung (M)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

X Zen Yap (XZ)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Amanda Fabra García (AF)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
ORCID: 0000-0001-6663-213X

Jan Pieter R Koopman (JPR)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Pauline Meij (P)

Interdivisional GMP Facility, Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Els Wessels (E)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Karina Teelen (K)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Youri M van Waardenburg (YM)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Marga van de Vegte-Bolmer (M)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Geert Jan van Gemert (GJ)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

Leo G Visser (LG)

Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
ORCID: 0000-0002-3600-9782

André J A M van der Ven (AJAM)

Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
ORCID: 0000-0003-1833-3391

Quirijn de Mast (Q)

Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

K C Natasha (KC)

Sanaria Inc., Rockville, MD 20850, USA.

Yonas Abebe (Y)

Sanaria Inc., Rockville, MD 20850, USA.

Tooba Murshedkar (T)

Sanaria Inc., Rockville, MD 20850, USA.

Peter F Billingsley (PF)

Sanaria Inc., Rockville, MD 20850, USA.
ORCID: 0000-0002-2946-5456

Tom L Richie (TL)

Sanaria Inc., Rockville, MD 20850, USA.
ORCID: 0000-0002-2946-5456

B Kim Lee Sim (BKL)

Sanaria Inc., Rockville, MD 20850, USA.
ORCID: 0000-0002-8598-8905

Chris J Janse (CJ)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Stephen L Hoffman (SL)

Sanaria Inc., Rockville, MD 20850, USA.
ORCID: 0000-0002-0700-9505

Shahid M Khan (SM)

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
ORCID: 0000-0002-0533-4670

Robert W Sauerwein (RW)

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands. robert.sauerwein@radboudumc.nl.
ORCID: 0000-0002-3163-7202

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiprotozoaires › Vaccins contre le paludisme › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Oocystes › Sporozoïtes › A double-blind, placebo-controlled phase 1/2a...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins atténués › A double-blind, placebo-controlled phase 1/2a...