HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption.
ART interruption
seminal plasma
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
16 07 2020
16 07 2020
Historique:
received:
10
03
2020
accepted:
11
05
2020
pubmed:
22
5
2020
medline:
20
11
2020
entrez:
22
5
2020
Statut:
epublish
Résumé
If strategies currently in development succeed in eradicating HIV reservoirs in peripheral blood and lymphoid tissues, residual sources of virus may remain in anatomic compartments. Paired blood and semen samples were collected from 12 individuals enrolled in a randomized, double-blind, placebo-controlled therapeutic vaccine clinical trial in people with HIV (PWH) who began antiretroviral therapy (ART) during acute or early infection (ClinicalTrials registration no. NCT01859325). After the week 56 visit (postintervention), all participants interrupted ART. At the first available time points after viral rebound, we sequenced HIV-1
Identifiants
pubmed: 32434884
pii: JVI.00415-20
doi: 10.1128/JVI.00415-20
pmc: PMC7375368
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
RNA, Viral
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI147821
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI131971
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118422
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI134295
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107345
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131385
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD094646
Pays : United States
Organisme : NIDA NIH HHS
ID : DP2 DA051915
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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