SARS-CoV-2 infection protects against rechallenge in rhesus macaques.

Animals Antibodies, Neutralizing / blood Antibodies, Viral / blood Betacoronavirus / immunology Bronchoalveolar Lavage Fluid / virology COVID-19 Coronavirus Infections / immunology Disease Models, Animal Female Immunity, Cellular Immunity, Humoral Immunologic Memory Lung / immunology Lung Diseases, Interstitial / immunology Macaca mulatta Male Nasal Mucosa / virology Pandemics Pneumonia, Viral / immunology Recurrence SARS-CoV-2 Spike Glycoprotein, Coronavirus / immunology Viral Load Virus Replication

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
14 08 2020
Historique:
received: 26 04 2020
accepted: 16 05 2020
pubmed: 22 5 2020
medline: 28 8 2020
entrez: 22 5 2020
Statut: ppublish

Résumé

An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global coronavirus disease 2019 (COVID-19) pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against reexposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. After the initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log

Identifiants

DOI: 10.1126/science.abc4776 PMID: 32434946 PMC: PMC7243369
pubmed: 32434946
pii: science.abc4776
doi: 10.1126/science.abc4776
pmc: PMC7243369
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

812-817

Subventions

Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI110700
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007151
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108197
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIH HHS
ID : S10 OD025002
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146779
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI149644
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100625
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129797
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA225088
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI135098
Pays : United States
Organisme : NIH HHS
ID : R01 OD024917
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132178
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Abishek Chandrashekar (A)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0001-7821-5552

Jinyan Liu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0003-0504-2181

Amanda J Martinot (AJ)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
ORCID: 0000-0001-6237-6191

Katherine McMahan (K)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-3933-0539

Noe B Mercado (NB)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0001-7769-7326

Lauren Peter (L)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-2105-7503

Lisa H Tostanoski (LH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0001-9255-5684

Jingyou Yu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-0775-6623

Zoltan Maliga (Z)

Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0003-4209-7253

Michael Nekorchuk (M)

Oregon Health & Sciences University, Beaverton, OR 97006, USA.

Kathleen Busman-Sahay (K)

Oregon Health & Sciences University, Beaverton, OR 97006, USA.
ORCID: 0000-0002-8549-0023

Margaret Terry (M)

Oregon Health & Sciences University, Beaverton, OR 97006, USA.
ORCID: 0000-0002-7260-9005

Linda M Wrijil (LM)

Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
ORCID: 0000-0003-0786-8390

Sarah Ducat (S)

Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
ORCID: 0000-0002-5285-7642

David R Martinez (DR)

University of North Carolina, Chapel Hill, NC 27599, USA.

Caroline Atyeo (C)

Harvard Medical School, Boston, MA 02115, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0002-7489-0232

Stephanie Fischinger (S)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0003-2307-3379

John S Burke (JS)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0003-1282-8211

Matthew D Slein (MD)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0001-8288-787X

Laurent Pessaint (L)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0002-2126-3008

Alex Van Ry (A)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0002-1240-9044

Jack Greenhouse (J)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0003-2325-8162

Tammy Taylor (T)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0001-7367-3271

Kelvin Blade (K)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0003-3387-6693

Anthony Cook (A)

Bioqual, Rockville, MD 20852, USA.

Brad Finneyfrock (B)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0002-1564-5798

Renita Brown (R)

Bioqual, Rockville, MD 20852, USA.

Elyse Teow (E)

Bioqual, Rockville, MD 20852, USA.

Jason Velasco (J)

Bioqual, Rockville, MD 20852, USA.

Roland Zahn (R)

Janssen Vaccines & Prevention BV, Leiden, Netherlands.
ORCID: 0000-0003-2822-6231

Frank Wegmann (F)

Janssen Vaccines & Prevention BV, Leiden, Netherlands.
ORCID: 0000-0002-9821-1492

Peter Abbink (P)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0003-1978-088X

Esther A Bondzie (EA)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0001-9409-5052

Gabriel Dagotto (G)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9872-6074

Makda S Gebre (MS)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-8520-2178

Xuan He (X)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Catherine Jacob-Dolan (C)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-6641-0342

Nicole Kordana (N)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0003-4082-6029

Zhenfeng Li (Z)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Michelle A Lifton (MA)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0003-0279-2198

Shant H Mahrokhian (SH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0003-4094-8739

Lori F Maxfield (LF)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-7595-6205

Ramya Nityanandam (R)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-3288-8505

Joseph P Nkolola (JP)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
ORCID: 0000-0002-0678-9765

Aaron G Schmidt (AG)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA.
ORCID: 0000-0003-3627-2553

Andrew D Miller (AD)

Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.
ORCID: 0000-0001-6350-5581

Ralph S Baric (RS)

University of North Carolina, Chapel Hill, NC 27599, USA.
ORCID: 0000-0001-6827-8701

Galit Alter (G)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA.
ORCID: 0000-0002-7680-9215

Peter K Sorger (PK)

Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-3364-1838

Jacob D Estes (JD)

Oregon Health & Sciences University, Beaverton, OR 97006, USA.
ORCID: 0000-0002-9652-6394

Hanne Andersen (H)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0003-1103-9608

Mark G Lewis (MG)

Bioqual, Rockville, MD 20852, USA.
ORCID: 0000-0001-7852-0135

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. dbarouch@bidmc.harvard.edu.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA.
ORCID: 0000-0001-5127-4659

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité humorale › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Appareil respiratoire › Poumon › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Muqueuse nasale › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › SARS-CoV-2 infection protects against...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › SARS-CoV-2 infection protects against...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › SARS-CoV-2 infection protects against...