MST1/2 Balance Immune Activation and Tolerance by Orchestrating Adhesion, Transcription, and Organelle Dynamics in Lymphocytes.
Animals
Cell Adhesion
Humans
Immune Tolerance
Immunological Synapses
Intracellular Signaling Peptides and Proteins
Lymphocyte Activation
Organelles
/ pathology
Protein Serine-Threonine Kinases
/ metabolism
Serine-Threonine Kinase 3
Signal Transduction
T-Lymphocytes
/ immunology
Transcription, Genetic
Mst1/2
cell polarity and adhesion
effector differentiation
integrin
lymphocyte trafficking
vesicle transport
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
12
2019
accepted:
31
03
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
18
3
2021
Statut:
epublish
Résumé
The STE20-like serine/threonine kinases MST1 and MST2 (MST1/2) are mammalian homologs of Hippo in flies. MST1/2 regulate organ size by suppressing the transcription factor YAP, which promotes proliferation. MST1 is predominantly expressed in immune cells, where it plays distinct roles. Here, we review the functions of MST1/2 in immune cells, uncovered by a series of recent studies, and discuss the connection between MST1/2 function and immune responses. MST1/2 regulate lymphocyte development, trafficking, survival, and antigen recognition by naive T cells. MST1/2 also regulate the function of regulatory T cells and effector T cell differentiation, thus acting to balance immune activation and tolerance. Interestingly, MST1/2 elicit these functions not by the "canonical" Hippo pathway, but by the non-canonical Hippo pathway or alternative pathways. In these pathways, MST1/2 regulates cellular processes relating to immune response, such as chemotaxis, cell adhesion, immunological synapse, gene transcriptions. Recent advances in our understanding of the molecular mechanisms of these processes have revealed important roles of MST1/2 in regulating cytoskeleton remodeling, integrin activation, and vesicular transport in lymphocytes. We discuss the significance of the MST1/2 signaling in lymphocytes in the regulation of organelle dynamics.
Identifiants
pubmed: 32435241
doi: 10.3389/fimmu.2020.00733
pmc: PMC7218056
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
STK4 protein, human
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
STK3 protein, human
EC 2.7.11.1
Serine-Threonine Kinase 3
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
733Informations de copyright
Copyright © 2020 Ueda, Kondo and Kinashi.
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