Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
14 May 2020
Historique:
received: 23 12 2019
accepted: 07 02 2020
entrez: 22 5 2020
pubmed: 22 5 2020
medline: 22 5 2020
Statut: epublish

Résumé

The marine natural product Largazole is the most potent Class I HDAC inhibitor identified to date. Since its discovery, many research groups have been attracted by the structural complexity and the peculiar anticancer activity, due to its capability to discriminate between tumor cells and normal cells. Herein, we discuss the synthesis and the

Identifiants

pubmed: 32435394
doi: 10.1021/acsmedchemlett.9b00643
pmc: PMC7236235
doi:

Types de publication

Journal Article

Langues

eng

Pagination

846-851

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Matteo Borgini (M)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Claudio Zamperini (C)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Lead Discovery Siena S.r.l., Castelnuovo Berardenga, 53019 Siena, Italy.

Federica Poggialini (F)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Luca Ferrante (L)

Promidis, Via Olgettina 60, 20132 Milano, Italy.

Vincenzo Summa (V)

IRBM Science Park, Via Pontina Km 30.600, 00070 Pomezia, Italy.

Maurizio Botta (M)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Lead Discovery Siena S.r.l., Castelnuovo Berardenga, 53019 Siena, Italy.
Biotechnology College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, United States.

Romano Di Fabio (RD)

Promidis, Via Olgettina 60, 20132 Milano, Italy.
IRBM Science Park, Via Pontina Km 30.600, 00070 Pomezia, Italy.

Classifications MeSH