Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
24
12
2019
accepted:
20
03
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
Gold nanoparticles (GNPs) have been proposed as carriers for drugs to improve their intrinsic therapeutic activities and to overcome pharmacokinetic problems. In this study, novel nanosystems constituted by a model β-diketo acid (DKA) grafted to the surface of GNPs were designed and synthesized following the "multivalent high-affinity" binding strategy. These first nanoscale DKA prototypes showed improved inhibition of HIV-1 integrase (HIV-1 IN) catalytic activities as compared with free DKA ligands.
Identifiants
pubmed: 32435396
doi: 10.1021/acsmedchemlett.9b00648
pmc: PMC7236234
doi:
Types de publication
Journal Article
Langues
eng
Pagination
857-861Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Anal Bioanal Chem. 2012 Apr;403(1):145-9
pubmed: 22349346
Pharm Nanotechnol. 2018;6(1):17-27
pubmed: 29424324
Science. 2000 Jan 28;287(5453):646-50
pubmed: 10649997
J Med Chem. 2011 Dec 22;54(24):8407-20
pubmed: 22066494
Cell. 1991 Dec 20;67(6):1211-21
pubmed: 1760846
J Am Chem Soc. 2008 Jun 4;130(22):6896-7
pubmed: 18473457
Nature. 2010 Mar 11;464(7286):232-6
pubmed: 20118915
J Biol Chem. 2019 Oct 11;294(41):15137-15157
pubmed: 31467082
Future Med Chem. 2015;7(9):1097-107
pubmed: 26132521
Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6572-81
pubmed: 22689381
Nat Rev Microbiol. 2013 Dec;11(12):877-83
pubmed: 24162027
Chem Rev. 2015 Oct 14;115(19):11147-90
pubmed: 26088284
Acc Chem Res. 2005 Sep;38(9):723-32
pubmed: 16171315
J Med Chem. 2006 Oct 5;49(20):6087-93
pubmed: 17004722
Org Biomol Chem. 2004 Dec 7;2(23):3409-24
pubmed: 15565230
Virology. 2011 Mar 15;411(2):194-205
pubmed: 21216426
J Am Chem Soc. 2007 Sep 19;129(37):11653-61
pubmed: 17718495
Drug Discov Today. 2015 Apr;20(4):435-49
pubmed: 25486307
J Am Chem Soc. 2008 Dec 3;130(48):16130-1
pubmed: 18989963
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20057-62
pubmed: 21030679
Future Sci OA. 2018 Sep 06;4(9):FSO338
pubmed: 30416746
Chem Rev. 2016 Oct 26;116(20):12730-12757
pubmed: 27198982
Curr Opin HIV AIDS. 2012 Sep;7(5):383-9
pubmed: 22871634
Bioconjug Chem. 2016 Nov 16;27(11):2646-2657
pubmed: 27689882
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6
pubmed: 11997448
J Med Chem. 2019 Dec 12;62(23):10475-10496
pubmed: 31339714
Nat Rev Drug Discov. 2005 Mar;4(3):236-48
pubmed: 15729361
J Med Chem. 2011 Mar 10;54(5):1170-7
pubmed: 21291238
Chem Rev. 2004 Jan;104(1):293-346
pubmed: 14719978
Chem Soc Rev. 2010 Aug;39(8):2817-26
pubmed: 20461247
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1339-43
pubmed: 1847518
Chem Soc Rev. 2012 Mar 21;41(6):2256-82
pubmed: 22130549
Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3280-94
pubmed: 20401880
Chem Rev. 2012 May 9;112(5):2739-79
pubmed: 22295941
Angew Chem Int Ed Engl. 1998 Nov 2;37(20):2754-2794
pubmed: 29711117
J Med Chem. 2004 Oct 7;47(21):5298-310
pubmed: 15456274