New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
30
12
2019
accepted:
28
02
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
Betulinic acid is validated as a new self-assembly inducer for the formation of nanoparticles (NPs) in combination with different drugs. The target compounds are characterized by the presence of anticancer drugs acting on tubulin dynamics and of a linker that could be a carbon chain or a triazole-based one. Nanoparticles formed are characterized and their biological activity is evaluated.
Identifiants
pubmed: 32435402
doi: 10.1021/acsmedchemlett.9b00668
pmc: PMC7236225
doi:
Types de publication
Journal Article
Langues
eng
Pagination
895-898Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Ann N Y Acad Sci. 2018 Jun;1421(1):5-18
pubmed: 29377164
Pharmaceutics. 2019 Aug 20;11(8):
pubmed: 31434235
Org Biomol Chem. 2017 Feb 1;15(5):1106-1109
pubmed: 28093593
Cancer Lett. 2002 Jan 10;175(1):17-25
pubmed: 11734332
Nat Commun. 2018 May 29;9(1):2106
pubmed: 29844393
Chempluschem. 2015 Sep;80(9):1380-1383
pubmed: 31973361
Eur J Med Chem. 2014 Oct 6;85:179-90
pubmed: 25084144
ACS Med Chem Lett. 2017 Aug 01;8(9):953-957
pubmed: 28947943
Drug Discov Today. 2017 Oct;22(10):1572-1581
pubmed: 28676407
Drug Discov Today. 2016 Aug;21(8):1321-9
pubmed: 27329268
ACS Med Chem Lett. 2018 Apr 17;9(5):468-471
pubmed: 29795761