A modified live bat influenza A virus-based vaccine prototype provides full protection against HPAIV H5N1.
Influenza virus
Live attenuated vaccines
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
12
2019
accepted:
15
04
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 fatal spillover infections from poultry to humans, with a looming danger of a new pandemic by establishing human-to-human transmissions. Besides culling measures in infected farms in endemic areas, vaccination is the major tool against HPAIV. However, the mainly used inactivated preparations have several limitations, like application to the individual animal by injection and a reduced efficiency. Here we present a modified live influenza vaccine prototype, which is based on the H17N10 bat influenza virus. The new chimeric vaccine strain R65
Identifiants
pubmed: 32435514
doi: 10.1038/s41541-020-0185-6
pii: 185
pmc: PMC7229168
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : BE 5187/2-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SCHW 632/16-1
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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