Multiplexed drug testing of tumor slices using a microfluidic platform.
Chemotherapy
Drug delivery
Nanobiotechnology
Journal
NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
06
2019
accepted:
25
03
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
Current methods to assess the drug response of individual human cancers are often inaccurate, costly, or slow. Functional approaches that rapidly and directly assess the response of patient cancer tissue to drugs or small molecules offer a promising way to improve drug testing, and have the potential to identify the best therapy for individual patients. We developed a digitally manufactured microfluidic platform for multiplexed drug testing of intact cancer slice cultures, and demonstrate the use of this platform to evaluate drug responses in slice cultures from human glioma xenografts and patient tumor biopsies. This approach retains much of the tissue microenvironment and can provide results rapidly enough, within days of surgery, to guide the choice of effective initial therapies. Our results establish a useful preclinical platform for cancer drug testing and development with the potential to improve cancer personalized medicine.
Identifiants
pubmed: 32435696
doi: 10.1038/s41698-020-0117-y
pii: 117
pmc: PMC7237421
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12Subventions
Organisme : NCI NIH HHS
ID : P01 CA077852
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA181445
Pays : United States
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe microfluidic device is covered under US patent 20140113838A1, on which L.F.H., R.J.M., A.F., and R.C.R. are inventors. L.F.H. and A.F. are founders of OncoFluidics, LLC.
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