Drug rechanneling: A novel paradigm for cancer treatment.
Anti-Diabetic drugs
Anti-Malarial drugs
Anti-Psychotic drugs
Anti-Viral drugs
Cancer
Repurposing
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
16
09
2019
revised:
15
01
2020
accepted:
18
03
2020
pubmed:
22
5
2020
medline:
1
3
2022
entrez:
22
5
2020
Statut:
ppublish
Résumé
Cancer continues to be one of the leading contributors towards global disease burden. According to NIH, cancer incidence rate per year will increase to 23.6 million by 2030. Even though cancer continues to be a major proportion of the disease burden worldwide, it has the lowest clinical trial success rate amongst other diseases. Hence, there is an unmet need for novel, affordable and effective anti-neoplastic medications. As a result, a growing interest has sparkled amongst researchers towards drug repurposing. Drug repurposing follows the principle of polypharmacology, which states, "any drug with multiple targets or off targets can present several modes of action". Drug repurposing also known as drug rechanneling, or drug repositioning is an economic and reliable approach that identifies new disease treatment of already approved drugs. Repurposing guarantees expedited access of drugs to the patients as these drugs are already FDA approved and their safety and toxicity profile is completely established. Epidemiological studies have identified the decreased occurrence of oncological or non-oncological conditions in patients undergoing treatment with FDA approved drugs. Data from multiple experimental studies and clinical observations have depicted that several non-neoplastic drugs have potential anticancer activity. In this review, we have summarized the potential anti-cancer effects of anti-psychotic, anti-malarial, anti-viral and anti-emetic drugs with a brief overview on their mechanism and pathways in different cancer types. This review highlights promising evidences for the repurposing of drugs in oncology.
Identifiants
pubmed: 32437876
pii: S1044-579X(20)30077-8
doi: 10.1016/j.semcancer.2020.03.011
pmc: PMC7786449
mid: NIHMS1596670
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
279-290Subventions
Organisme : NCI NIH HHS
ID : R01 CA129038
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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