Identification of Prevotella Oralis as a possible target antigen in children with Enthesitis related arthritis.
Antibodies
Enthesitis-related arthritis
Immunoglobulin A
Prevotella
Spondyloarthritis
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
15
04
2020
revised:
07
05
2020
accepted:
08
05
2020
pubmed:
22
5
2020
medline:
2
2
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
Patients with Crohn's disease often produce antibodies against flagellated intestinal bacteria. There are mixed data as to whether such antibodies are present in patients with spondyloarthritis. Our objectives were to evaluate for the presence of antibodies against intestinal organisms in children with enthesitis related arthritis (ERA). Children with ERA and healthy controls were recruited at three sites. Sera were plated on a nitrocellulose array and incubated with labelled antibodies to human IgA and IgG. At UAB, patients and controls had similar antibody levels against the majority of the bacteria selected, with the exception of increased IgA antibodies among ERA patients against Prevotella oralis (1231 [IQR 750, 2566] versus 706 [IQR 428, 1106], p = .007.) These findings were partially validated at a second but not at a third site. ERA patients may produce increased IgA antibodies against P. oralis. The possible significance of this finding bears further exploration.
Identifiants
pubmed: 32437923
pii: S1521-6616(20)30272-2
doi: 10.1016/j.clim.2020.108463
pmc: PMC7338258
mid: NIHMS1595821
pii:
doi:
Substances chimiques
Antigens, Bacterial
0
Immunoglobulin A
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108463Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR069625
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070253
Pays : United States
Organisme : NIAMS NIH HHS
ID : P01 AR048929
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070549
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AR041184
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR064172
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR047363
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065538
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007512
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
Références
Clin Exp Immunol. 2017 Mar;187(3):480-489
pubmed: 27861762
Gastroenterology. 2005 Jun;128(7):2020-8
pubmed: 15940634
J Rheumatol. 2004 May;31(5):920-4
pubmed: 15124251
Arthritis Res Ther. 2014 Nov 30;16(6):486
pubmed: 25434931
J Immunol. 1996 Jan 15;156(2):794-803
pubmed: 8543835
J Allergy Clin Immunol. 2015 Nov;136(5):1378-86.e1-5
pubmed: 26014812
Arthritis Rheumatol. 2017 Jan;69(1):114-121
pubmed: 27390077
Carbohydr Res. 2010 Jan 11;345(1):108-14
pubmed: 19897181
Inflamm Bowel Dis. 2007 Oct;13(10):1191-201
pubmed: 17712838
Arthritis Res Ther. 2018 Jan 30;20(1):14
pubmed: 29382366
J Rheumatol. 2004 Feb;31(2):390-2
pubmed: 14760812
Ann Rheum Dis. 2003 May;62(5):455-9
pubmed: 12695160
JAMA. 2017 Mar 28;317(12):1258-1268
pubmed: 28350935
Arthritis Rheum. 2009 Jul;60(7):1977-84
pubmed: 19565478
J Rheumatol. 2011 Oct;38(10):2274-5
pubmed: 21965700
Arthritis Rheumatol. 2015 Mar;67(3):686-691
pubmed: 25417597
Curr Opin Rheumatol. 2016 Sep;28(5):537-43
pubmed: 27286235
Gut Microbes. 2012 Jan-Feb;3(1):4-14
pubmed: 22356853
Arthritis Res Ther. 2013 Oct 26;15(5):R166
pubmed: 24286190
J Clin Invest. 2004 May;113(9):1296-306
pubmed: 15124021
Medicine (Baltimore). 2018 Aug;97(32):e11772
pubmed: 30095633
Arthritis Rheum. 2008 Mar;58(3):730-3
pubmed: 18311807
J Exp Med. 1994 Dec 1;180(6):2359-64
pubmed: 7964509
Pediatr Rheumatol Online J. 2016 Jul 22;14(1):44
pubmed: 27448997
Gastroenterology. 2010 Dec;139(6):1844-1854.e1
pubmed: 20816835
Pediatrics. 2012 May;129(5):950-60
pubmed: 22473366
Arthritis Rheum. 2009 Jul;60(7):2102-12
pubmed: 19565513
J Rheumatol. 1991 Oct;18(10):1542-51
pubmed: 1765980
Curr Rheumatol Rep. 2005 Jun;7(3):188-94
pubmed: 15918994
J Proteome Res. 2010 Dec 3;9(12):6135-47
pubmed: 20932056
Gastroenterol Res Pract. 2014;2014:872725
pubmed: 24799893
Cell Host Microbe. 2014 Mar 12;15(3):382-392
pubmed: 24629344
Immunol Rev. 2010 Jan;233(1):181-202
pubmed: 20193000
Best Pract Res Clin Rheumatol. 2017 Dec;31(6):797-815
pubmed: 30509441
Ann Rheum Dis. 2017 Sep;76(9):1614-1622
pubmed: 28606969