Development and skin penetration pathway evaluation of microemulsions for enhancing the dermal delivery of celecoxib.
Administration, Cutaneous
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Celecoxib
/ administration & dosage
Cell Line
Drug Carriers
/ administration & dosage
Drug Delivery Systems
Emulsions
/ administration & dosage
Glycerides
/ administration & dosage
Particle Size
Skin
/ drug effects
Skin Absorption
/ drug effects
Solubility
Surface Properties
Swine
Celecoxib
Dermal delivery
Microemulsion
Skin penetration pathway
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
11
03
2020
revised:
28
04
2020
accepted:
29
04
2020
pubmed:
22
5
2020
medline:
4
2
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
This study aimed to develop a microemulsion using PEG-6 Caprylic/Capric Glycerides as a surfactant to enhance the dermal delivery of celecoxib. Confocal laser scanning microscopy (CLSM) using the colocalization technique was also used to investigate the skin penetration pathway of the microemulsion. The prepared microemulsion formulations were characterized in terms of size, surface charge, size distribution and type. The celecoxib-loaded microemulsion had particle sizes ranging from 48 to 214 nm with neutral charge and significantly increased the skin penetration of celecoxib. According to the CLSM study, the microemulsion might attach to any part of the skin before releasing the entrapped drug to penetrate the tissue. The transfollicular pathway might be the major skin penetration pathway for the microemulsion, whereas the intercellular and transcellular pathways are minor ones.
Identifiants
pubmed: 32438237
pii: S0927-7765(20)30333-7
doi: 10.1016/j.colsurfb.2020.111103
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Drug Carriers
0
Emulsions
0
Glycerides
0
Celecoxib
JCX84Q7J1L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111103Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.