Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults.
Aged
Aged, 80 and over
Aging
/ cerebrospinal fluid
Amyloid beta-Peptides
/ cerebrospinal fluid
Atrophy
Biomarkers
/ cerebrospinal fluid
Chitinase-3-Like Protein 1
/ cerebrospinal fluid
Cognitive Dysfunction
/ diagnosis
Fatty Acid Binding Protein 3
/ cerebrospinal fluid
Female
Hippocampus
/ pathology
Humans
Male
Memory
Middle Aged
Neurofilament Proteins
/ cerebrospinal fluid
Peptide Fragments
/ cerebrospinal fluid
Predictive Value of Tests
tau Proteins
/ cerebrospinal fluid
Beta amyloid 1–42
Biomarkers
Cerebrospinal fluid
Chitinase-3-like protein 1
Fatty acid binding protein 3
Hippocampal atrophy
Magnetic resonance imaging
Memory
Neurofilament light
Phosphorylated tau
Total tau
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
10
02
2019
revised:
30
03
2020
accepted:
06
04
2020
pubmed:
22
5
2020
medline:
16
1
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1-42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain β-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Aβ42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline.
Identifiants
pubmed: 32438258
pii: S0197-4580(20)30121-4
doi: 10.1016/j.neurobiolaging.2020.04.002
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
CHI3L1 protein, human
0
Chitinase-3-Like Protein 1
0
FABP3 protein, human
0
Fatty Acid Binding Protein 3
0
Neurofilament Proteins
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
neurofilament protein L
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-15Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.