Irreversible electroporation is a thermally mediated ablation modality for pulses on the order of one microsecond.
Algorithmically controlled electroporation
Electro-thermal therapy
High frequency irreversible electroporation
Thermally mediated electroporation
Journal
Bioelectrochemistry (Amsterdam, Netherlands)
ISSN: 1878-562X
Titre abrégé: Bioelectrochemistry
Pays: Netherlands
ID NLM: 100953583
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
09
01
2020
revised:
29
04
2020
accepted:
29
04
2020
pubmed:
22
5
2020
medline:
13
3
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
Irreversible electroporation (IRE) is generally considered to be a non-thermal ablation modality. This study was designed to examine the relative effect of temperature on IRE ablation sizes for equivalent dose treatments with constitutive pulses between 1 and 100 µs. 3D in-vitro brain tumor models maintained at 10 °C, 20 °C, 30 °C, or 37 °C were exposed to 500 V treatments using a temperature control algorithm to limit temperature increases to 5 °C. Treatments consisted of integrated energized times (doses) of 0.01 or 0.1 s. Pulse width, electrical dose, and initial temperature were all found to significantly affect the size of ablations and the resulting lethal electric field strength. The smallest ablations were created at 10 °C and E
Identifiants
pubmed: 32438309
pii: S1567-5394(20)30019-0
doi: 10.1016/j.bioelechem.2020.107544
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107544Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: MBS has issued and pending patents related to this manuscript and receives royalties from AngioDynamics Inc. CCF and RAP have pending patents related to this manuscript and may receive royalties in the future. The remaining authors have no competing interests to declare.