Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
24
04
2020
accepted:
18
05
2020
pubmed:
22
5
2020
medline:
30
9
2020
entrez:
22
5
2020
Statut:
ppublish
Résumé
There is a rapidly expanding literature on the in vitro antiviral activity of drugs that may be repurposed for therapy or chemoprophylaxis against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). However, this has not been accompanied by a comprehensive evaluation of the target plasma and lung concentrations of these drugs following approved dosing in humans. Accordingly, concentration 90% (EC
Identifiants
pubmed: 32438446
doi: 10.1002/cpt.1909
pmc: PMC7280633
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
775-790Subventions
Organisme : Medical Research Council
ID : MC_PC_17167
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R24 AI118397
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134091
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
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