Hypopharyngeal-Esophageal Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients.
Adult
Aged
Aged, 80 and over
Electric Impedance
Esophageal pH Monitoring
/ methods
Esophagus
/ physiopathology
Female
Humans
Hypopharynx
/ physiopathology
Laryngopharyngeal Reflux
/ diagnosis
Male
Middle Aged
Pepsin A
/ analysis
Photoperiod
Postprandial Period
/ physiology
Prospective Studies
Saliva
/ chemistry
Young Adult
Laryngopharyngeal
impedance
laryngitis
pH monitoring
pepsin
pharyngeal
profile
reflux
reflux episode
treatment
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
15
02
2020
revised:
17
04
2020
accepted:
21
04
2020
pubmed:
22
5
2020
medline:
22
1
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
To investigate the profile of patients with laryngopharyngeal reflux (LPR) at hypopharyngeal-esophageal multichannel intraluminal impedance-pH (HEMII-pH) monitoring and the relationship between hypopharyngeal-proximal reflux episodes (HREs) and saliva pepsin concentration. Prospective non-controlled. Patients were recruited from three European hospitals from January 2018 to October 2019. Patients benefited from HEMII-pH monitoring and saliva collections to measure saliva pepsin concentration in the same time. Saliva pepsin concentration was measured in the morning (fasting), after lunch, and after dinner. The LPR profile of patients was studied through a breakdown of the HEMII-pH findings over the 24 hours of testing. The relationship between the concentrations of saliva pepsin and 24-hour HREs was studied through linear multiple regression. One hundred twenty-six patients completed the study. The HEMII-pH analyses revealed that 73.99% of HREs occurred outside 1-hour postmeal times, whereas 20.49% and 5.52% of HREs occurred during the 1-hour postmeal and nighttime, respectively. Seventy-four patients (58.73%) did not have nighttime HREs. Patients with both daytime and nighttime HREs had more severe HEMII-pH parameters and reflux symptom score compared with patients with only daytime HREs. There were no significant associations between HREs and saliva pepsin concentration. Unlike gastroesophageal reflux disease, HREs occur less frequently after meals and nighttime. The analysis of the HEMII-pH profile of the LPR patients has to be considered to develop future personalized therapeutic strategies. 4 Laryngoscope, 131:268-276, 2021.
Substances chimiques
Pepsin A
EC 3.4.23.1
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
268-276Subventions
Organisme : IRIS Recherche
ID : 2018
Pays : International
Informations de copyright
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.
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