Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism.

HUVEC M2 macrophages OXPHOS RiPPs TAM-like macrophages flow cytometry migration mitochondria phagocytosis qPCR scratch assay thioviridamide-like compounds

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
19 May 2020
Historique:
received: 09 04 2020
revised: 12 05 2020
accepted: 13 05 2020
entrez: 23 5 2020
pubmed: 23 5 2020
medline: 23 5 2020
Statut: epublish

Résumé

Natural products represent powerful tools searching for novel anticancer drugs. Thioholgamide A (thioA) is a ribosomally synthesized and post-translationally modified peptide, which has been identified as a product of

Identifiants

pubmed: 32438733
pii: cancers12051288
doi: 10.3390/cancers12051288
pmc: PMC7281193
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : KI702
Organisme : Saarland Landesforschungsförderung
ID : LFFP 17/08

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Auteurs

Charlotte Dahlem (C)

Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.

Wei Xiong Siow (WX)

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5-13, 81377 Munich, Germany.

Maria Lopatniuk (M)

Department of Pharmacy, Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.

William K F Tse (WKF)

Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan.

Sonja M Kessler (SM)

Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.
Department of Pharmacology for Natural Sciences, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.

Susanne H Kirsch (SH)

Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Campus E8 1, 66123 Saarbrücken, Germany.

Jessica Hoppstädter (J)

Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.

Angelika M Vollmar (AM)

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5-13, 81377 Munich, Germany.

Rolf Müller (R)

Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Campus E8 1, 66123 Saarbrücken, Germany.
Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.

Andriy Luzhetskyy (A)

Department of Pharmacy, Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.
Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Campus E8 1, 66123 Saarbrücken, Germany.

Karin Bartel (K)

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5-13, 81377 Munich, Germany.

Alexandra K Kiemer (AK)

Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.

Classifications MeSH