Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study.
Anti-Asthmatic Agents
/ therapeutic use
Asthma
/ diagnosis
Child, Preschool
Cohort Studies
Drug Prescriptions
/ statistics & numerical data
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Japan
/ epidemiology
Male
Maternal Exposure
/ adverse effects
Mothers
/ statistics & numerical data
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Risk Assessment
/ statistics & numerical data
Smoking
/ adverse effects
Surveys and Questionnaires
/ statistics & numerical data
Tobacco Smoke Pollution
/ adverse effects
Asthma
Child
Passive smoking
Prospective studies
Second-hand smoke
Journal
Allergologia et immunopathologia
ISSN: 1578-1267
Titre abrégé: Allergol Immunopathol (Madr)
Pays: Singapore
ID NLM: 0370073
Informations de publication
Date de publication:
Historique:
received:
11
12
2019
revised:
10
03
2020
accepted:
17
03
2020
pubmed:
23
5
2020
medline:
7
9
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
There is limited evidence on the association between prenatal smoking exposure and the risk of asthma in children. The aim of this prebirth cohort study was to investigate the association between prenatal and postnatal tobacco smoke exposure and the risk of asthma in Japanese children. Study subjects were 1304 mother-child pairs. Information on the variables under study was obtained using repeated questionnaires that were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, 24, and 36 months after delivery. Ever asthma was defined as a maternal report of physician-diagnosed asthma at any time since birth. Current asthma was defined as the use of asthma medication at the time of the sixth survey. Logistic regression models revealed that maternal active smoking, either before pregnancy or during pregnancy, was not associated with the risk of ever asthma or current asthma. Further, no association was observed between postnatally living with at least one household smoker and the risk of asthma. Among children whose mothers are never smokers, maternal second-hand smoke (SHS) exposure at work and/or at home during pregnancy increased the risk of ever asthma and current asthma in children; adjusted odds ratio (95% confidence intervals) for ever asthma and current asthma were 2.41 (1.13-5.05) and 4.82 (1.68-13.43), respectively. Our findings suggest that maternal SHS exposure during pregnancy might be associated with an increased risk of ever asthma and current asthma in young children whose mothers have never smoked.
Sections du résumé
BACKGROUND
BACKGROUND
There is limited evidence on the association between prenatal smoking exposure and the risk of asthma in children. The aim of this prebirth cohort study was to investigate the association between prenatal and postnatal tobacco smoke exposure and the risk of asthma in Japanese children.
METHODS
METHODS
Study subjects were 1304 mother-child pairs. Information on the variables under study was obtained using repeated questionnaires that were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, 24, and 36 months after delivery. Ever asthma was defined as a maternal report of physician-diagnosed asthma at any time since birth. Current asthma was defined as the use of asthma medication at the time of the sixth survey.
RESULTS
RESULTS
Logistic regression models revealed that maternal active smoking, either before pregnancy or during pregnancy, was not associated with the risk of ever asthma or current asthma. Further, no association was observed between postnatally living with at least one household smoker and the risk of asthma. Among children whose mothers are never smokers, maternal second-hand smoke (SHS) exposure at work and/or at home during pregnancy increased the risk of ever asthma and current asthma in children; adjusted odds ratio (95% confidence intervals) for ever asthma and current asthma were 2.41 (1.13-5.05) and 4.82 (1.68-13.43), respectively.
CONCLUSIONS
CONCLUSIONS
Our findings suggest that maternal SHS exposure during pregnancy might be associated with an increased risk of ever asthma and current asthma in young children whose mothers have never smoked.
Identifiants
pubmed: 32439145
pii: S0301-0546(20)30068-9
doi: 10.1016/j.aller.2020.03.008
pii:
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Tobacco Smoke Pollution
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-536Informations de copyright
Copyright © 2020 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.