Determination of grapiprant plasma and urine concentrations in horses.
NSAID
grapiprant
horse
pharmacokinetics
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
09
2019
revised:
09
04
2020
accepted:
12
04
2020
pubmed:
23
5
2020
medline:
22
6
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase (COX) in tissues and used as therapeutic agents in different species. Grapiprant, a member of the piprant class of compounds, antagonizes prostaglandin receptors. It is a highly selective EP4 prostaglandin E Experimental study. A total of six healthy, adult mixed-breed mares weighing 502 ± 66 (397-600) kg and aged 14.8 ± 5.3 (6-21) years. Mares were administered one dose of 2 mg kg Grapiprant plasma concentrations ranged from 71 to 149 ng mL Currently, there are no published studies looking at the pharmacodynamics of grapiprant in horses. The effective concentration needed to control pain in dogs ranges 114-164 ng mL
Identifiants
pubmed: 32439238
pii: S1467-2987(20)30085-4
doi: 10.1016/j.vaa.2020.04.006
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Sulfonylurea Compounds
0
grapiprant
J9F5ZPH7NB
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
705-709Informations de copyright
Copyright © 2020 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.