Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis.

Animals Anxiety Anxiety Disorders Fear Humans Predatory Behavior
Animal models Anxiety Bench-to-bedside gap Fear Predator-prey models Translational neuroscience

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
08 2020
Historique:
received: 12 02 2020
revised: 28 04 2020
accepted: 03 05 2020
pubmed: 23 5 2020
medline: 22 6 2021
entrez: 23 5 2020
Statut: ppublish

Résumé

A better understanding of context in decision-making-that is, the internal and external conditions that modulate decisions-is required to help bridge the gap between natural behaviors that evolved by natural selection and more arbitrary laboratory models of anxiety and fear. Because anxiety and fear are mechanisms evolved to manage threats from predators and other exigencies, the large behavioral, ecological and evolutionary literature on predation risk is useful for re-framing experimental research on human anxiety-related disorders. We review the trade-offs that are commonly made during antipredator decision-making in wild animals along with the context under which the behavior is performed and measured, and highlight their relevance for focused laboratory models of fear and anxiety. We then develop an integrative mechanistic model of decision-making under risk which, when applied to laboratory and field settings, should improve studies of the biological basis of normal and pathological anxiety and may therefore improve translational outcomes.

Identifiants

DOI: 10.1016/j.neubiorev.2020.05.002 PMID: 32439371
pubmed: 32439371
pii: S0149-7634(20)30397-3
doi: 10.1016/j.neubiorev.2020.05.002
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

25-33

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare no conflicts of interest.

Auteurs

Markus Fendt (M)

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany; Center of Behavioral Brain Sciences (CBBS), Otto-von-Guericke University Magdeburg, Magdeburg, Germany. Electronic address: markus.fendt@med.ovgu.de.

Michael H Parsons (MH)

Department of Biological Sciences, Fordham University, Bronx, NY, USA.

Raimund Apfelbach (R)

University of Tübingen, Zoological Institute, Neurobiology, Tübingen, Germany.

Alexandra J R Carthey (AJR)

Department of Biological Sciences, Macquarie University, North Ryde, NSW, Australia.

Chris R Dickman (CR)

University of Sydney, School of Life and Environmental Sciences, Sydney, NSW, Australia.

Thomas Endres (T)

Institute for Physiology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Anke S K Frank (ASK)

University of Sydney, School of Life and Environmental Sciences, Sydney, NSW, Australia; University of Tasmania, School of Natural Sciences, Australia; University of Cologne, Institute of Botany, Cologne, Germany.

Daniel E Heinz (DE)

Max Planck School of Cognition, Leipzig, Germany; Max Planck Institute of Psychiatry, Max Planck Institute of Psychiatry, RG Neuronal Plasticity, Munich, Germany.

Menna E Jones (ME)

University of Tasmania, School of Natural Sciences, Australia.

Yasushi Kiyokawa (Y)

Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo, Japan.

Judith C Kreutzmann (JC)

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Karin Roelofs (K)

Donders Institute for Brain Cognition and Behaviour and Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands.

Miriam Schneider (M)

APOPO, Sokoine University of Agriculture, Morogoro, Tanzania.

Julia Sulger (J)

Max Planck Institute of Psychiatry, Max Planck Institute of Psychiatry, RG Neuronal Plasticity, Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.

Carsten T Wotjak (CT)

Max Planck Institute of Psychiatry, Max Planck Institute of Psychiatry, RG Neuronal Plasticity, Munich, Germany.

Daniel T Blumstein (DT)

University of California Los Angeles, Department of Ecology and Evolutionary Biology, Los Angeles, CA, USA. Electronic address: marmots@ucla.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Context and trade-offs characterize real-world...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Context and trade-offs characterize real-world...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Context and trade-offs characterize real-world...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Peur › Context and trade-offs characterize real-world...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Context and trade-offs characterize real-world...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Acte consommatoire › Comportement prédateur › Context and trade-offs characterize real-world...