Bio-inspired apatite particles limit skin penetration of drugs for dermatology applications.

Animals Apatites Dermatology Drug Carriers Nanoparticles Skin Swine
Apatite nanoparticles Calcium phosphate Permeation Skin penetration Topical administration

Journal

Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144

Informations de publication

Date de publication:
15 07 2020
Historique:
received: 24 02 2020
revised: 21 04 2020
accepted: 08 05 2020
pubmed: 23 5 2020
medline: 15 5 2021
entrez: 23 5 2020
Statut: ppublish

Résumé

Most treatments of skin pathologies involve local administration of active agents. One issue can however be the partial transcutaneous diffusion of the drug to blood circulation, leading to undesirable effects. In this work, the original use of submicron mineral particles based on bio-inspired calcium phosphate apatite was explored for the first time as drug carriers for favoring topical delivery. The permeation of a model drug across synthetic and biological membranes was investigated in both static and dynamic conditions. Our data show that adsorption of the drug on the apatite particles surface drastically limits its permeation, with lower effective diffusion coefficients (P

Identifiants

DOI: 10.1016/j.actbio.2020.05.010 PMID: 32439611
pubmed: 32439611
pii: S1742-7061(20)30280-4
doi: 10.1016/j.actbio.2020.05.010
pii:
doi:

Substances chimiques

Apatites 0
Drug Carriers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

418-428

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Auteurs

Maëla Choimet (M)

CIRIMAT, Université de Toulouse, CNRS/INP/UT3, Ensiacet, 4 allée E. Monso, 31030 Toulouse cedex 4, France; CIRIMAT, Université de Toulouse, Faculté des Sciences Pharmaceutiques, 35 Chemin des Maraîchers, 31400 Toulouse, France; SEPPIC - Air Liquide Healthcare, 127 Chemin de la Poudrerie, 81105 Castres, France.

Audrey Tourrette (A)

CIRIMAT, Université de Toulouse, Faculté des Sciences Pharmaceutiques, 35 Chemin des Maraîchers, 31400 Toulouse, France. Electronic address: Audrey.tourrette@univ-tlse3.fr.

Olivier Marsan (O)

CIRIMAT, Université de Toulouse, CNRS/INP/UT3, Ensiacet, 4 allée E. Monso, 31030 Toulouse cedex 4, France.

Giovanna Rassu (G)

Department of Chemistry and Pharmacy, University of Sassari, Via Muroni 23/a, 07100 Sassari, Italy.

Christophe Drouet (C)

CIRIMAT, Université de Toulouse, CNRS/INP/UT3, Ensiacet, 4 allée E. Monso, 31030 Toulouse cedex 4, France. Electronic address: christophe.drouet@cirimat.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Professions de santé › Médecine › Dermatologie › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Système tégumentaire › Peau › Bio-inspired apatite particles limit skin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Bio-inspired apatite particles limit skin...