Oligodendrocyte ARNT2 expression is altered in models of MS.
Animals
Aryl Hydrocarbon Receptor Nuclear Translocator
/ metabolism
Basic Helix-Loop-Helix Transcription Factors
/ metabolism
Cell Line
Cells, Cultured
Cerebral Cortex
/ metabolism
Embryo, Mammalian
Encephalomyelitis, Autoimmune, Experimental
/ metabolism
Female
Mice
Mice, Inbred C57BL
Multiple Sclerosis
/ metabolism
Oligodendrocyte Precursor Cells
/ metabolism
Oligodendroglia
/ metabolism
Journal
Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
19
10
2019
accepted:
16
03
2020
entrez:
23
5
2020
pubmed:
23
5
2020
medline:
14
9
2021
Statut:
epublish
Résumé
We examined expression of aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), a basic-loop-helix transcription factor implicated in neuronal development and axonal health, in oligodendrocyte (OL) cultures and over the course of chronic experimental autoimmune encephalomyelitis (EAE), the murine model of multiple sclerosis (MS). We assessed OL ARNT2 expression in EAE compared with sham-immunized controls and also in OL primary cultures and over the course of dibutyryl cyclic adenosine monophosphate (dbcAMP)-mediated maturation of the immortalized Oli-neu cell line. We also tested the functional role of ARNT2 in influencing OL characteristics using small interfering RNA (siRNA). ARNT2 is localized to Olig2 The analysis of ARNT2 expression in OLs demonstrates that OL ARNT2 expression is altered in EAE and during OL maturation. Findings point to ARNT2 as an important mediator of OL viability and differentiation and warrant further characterization as a target for intervention in demyelinating disorders such as MS.
Identifiants
pubmed: 32439712
pii: 7/4/e745
doi: 10.1212/NXI.0000000000000745
pmc: PMC7251514
pii:
doi:
Substances chimiques
Arnt2 protein, mouse
0
Basic Helix-Loop-Helix Transcription Factors
0
Aryl Hydrocarbon Receptor Nuclear Translocator
138391-32-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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