Previously undiagnosed neuroendocrine tumour mimicking breast cancer metastasis to the orbit.
Adenocarcinoma
/ pathology
Aged
Antineoplastic Agents, Hormonal
/ therapeutic use
Breast Neoplasms
/ secondary
Diplopia
Female
Humans
Intestinal Neoplasms
/ pathology
Neuroendocrine Tumors
/ pathology
Octreotide
/ therapeutic use
Orbit
Orbital Neoplasms
/ secondary
Pancreatic Neoplasms
/ pathology
Stomach Neoplasms
/ pathology
oncology
ophthalmology
pathology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
20 May 2020
20 May 2020
Historique:
entrez:
23
5
2020
pubmed:
23
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Metastatic neuroendocrine neoplasms to the breast are rare and histopathologic overlap with mammary carcinomas has led to misdiagnosis. We present a case of a middle-aged woman with diplopia and a right medial rectus mass. Metastatic breast cancer was initially suspected based on a history of invasive ductal carcinoma. Detailed immunohistochemistry of the orbital biopsy, gallium-68 dotatate positron emission tomography-CT, and reevaluation of her prior breast specimen, demonstrated that her initial breast carcinoma diagnosis was in error and she was ultimately diagnosed with a previously unknown gastrointestinal neuroendocrine tumour metastatic to both the orbit and breast. This case highlights the challenges of differentiating between metastatic neuroendocrine tumours and invasive mammary carcinomas with neuroendocrine differentiation both in the breast and in the orbit. It is important to recognise the overlap so that a primary neuroendocrine neoplasm is not missed, or treatment significantly delayed.
Identifiants
pubmed: 32439746
pii: 13/5/e234629
doi: 10.1136/bcr-2020-234629
pmc: PMC7247416
pii:
doi:
Substances chimiques
Antineoplastic Agents, Hormonal
0
Octreotide
RWM8CCW8GP
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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