Acute ischaemic stroke following cisplatin-based chemotherapy for testicular cancer.
chemotherapy
stroke
urological cancer
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
20 May 2020
20 May 2020
Historique:
entrez:
23
5
2020
pubmed:
23
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Cisplatin is a widely used chemotherapeutic agent for many cancer types. Its toxicity profile includes drug-induced vascular damage. Clinicians should be aware of its varied presentation, including acute and chronic vascular events involving the arterial and venous system. This is a case of an otherwise well 32-year-old man with testicular cancer who received bleomycin/etoposide/cisplatin, and presented following two cycles of chemotherapy with homonymous hemianopia secondary to acute stroke. Acute arterial complications are rare, but clinicians should maintain a high index of suspicion for such events, even in a patient who otherwise has no vascular risk factors. Primary and secondary prevention measures including lifestyle modifications (smoking cessation, diet and exercise), blood pressure and cholesterol management, and antiplatelet therapy should be considered in patients exposed to cisplatin, during and following their treatment.
Identifiants
pubmed: 32439748
pii: 13/5/e235005
doi: 10.1136/bcr-2020-235005
pmc: PMC7247405
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Platelet Aggregation Inhibitors
0
Clopidogrel
A74586SNO7
Cisplatin
Q20Q21Q62J
Aspirin
R16CO5Y76E
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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