Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Arrhythmias, Cardiac / genetics Cardiovascular Diseases / genetics Electrocardiography Endophenotypes Female Gene Expression Genetic Loci / genetics Genetic Predisposition to Disease / genetics Genetic Variation Genome-Wide Association Study Humans Male Multifactorial Inheritance Quantitative Trait Loci / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
21 05 2020
Historique:
received: 02 08 2019
accepted: 18 03 2020
entrez: 23 5 2020
pubmed: 23 5 2020
medline: 18 8 2020
Statut: epublish

Résumé

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.

Identifiants

DOI: 10.1038/s41467-020-15706-x PMID: 32439900 PMC: PMC7242331
pubmed: 32439900
doi: 10.1038/s41467-020-15706-x
pii: 10.1038/s41467-020-15706-x
pmc: PMC7242331
doi:

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

2542

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140187
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL148521
Pays : United States
Organisme : Medical Research Council
ID : MR/N025083/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/20/18/35058
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL092577
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : Medical Research Council
ID : G9521010
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/59/33139
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U01 HL137162
Pays : United States

Références

Cheng, S. et al. Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA 301, 2571–7 (2009).
pubmed: 19549974 pmcid: 2765917 doi: 10.1001/jama.2009.888
Alonso, A. et al. Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: the CHARGE-AF consortium. J. Am. Heart Assoc. 2, e000102 (2013).
pubmed: 23537808 pmcid: 3647274 doi: 10.1161/JAHA.112.000102
Rasmussen, P. V. et al. Electrocardiographic PR Interval Duration and Cardiovascular Risk: Results From the Copenhagen ECG Study. Can. J. Cardiol. 33, 674–681 (2017).
pubmed: 28449838 doi: 10.1016/j.cjca.2017.02.015
Butler, A. M. et al. Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. Circ. Cardiovasc. Genet. 5, 639–46 (2012).
pubmed: 23139255 pmcid: 3560365 doi: 10.1161/CIRCGENETICS.112.963991
Chambers, J. C. et al. Genetic variation in SCN10A influences cardiac conduction. Nat. Genet. 42, 149–52 (2010).
pubmed: 20062061 doi: 10.1038/ng.516
Holm, H. et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat. Genet. 42, 117–22 (2010).
pubmed: 20062063 doi: 10.1038/ng.511
Hong, K. W. et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum. Mol. Genet. 23, 6659–67 (2014).
pubmed: 25035420 doi: 10.1093/hmg/ddu374
Pfeufer, A. et al. Genome-wide association study of PR interval. Nat. Genet. 42, 153–9 (2010).
pubmed: 20062060 pmcid: 2850197 doi: 10.1038/ng.517
Sano, M. et al. Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. Hum. Mol. Genet. 23, 6668–76 (2014).
pubmed: 25055868 doi: 10.1093/hmg/ddu375
van Setten, J. et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nat. Commun. 9, 2904 (2018).
pubmed: 30046033 pmcid: 6060178 doi: 10.1038/s41467-018-04766-9
Verweij, N. et al. Genetic determinants of P wave duration and PR segment. Circ. Cardiovasc. Genet. 7, 475–81 (2014).
pubmed: 24850809 pmcid: 4141024 doi: 10.1161/CIRCGENETICS.113.000373
van Setten, J. et al. Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. Eur. J. Hum. Genet. 27, 952–962 (2019).
Lin, H. et al. Common and rare coding genetic variation underlying the electrocardiographic PR interval. Circ. Genom. Precis Med 11, e002037 (2018).
pubmed: 29748316 pmcid: 5951629
Genomes Project, C. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015).
doi: 10.1038/nature15393
Liu, Y. et al. SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis. Oncogene 37, 768–776 (2018).
pubmed: 29059170 doi: 10.1038/onc.2017.370
Holm, H. et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat. Genet 43, 316–20 (2011).
pubmed: 21378987 pmcid: 3066272 doi: 10.1038/ng.781
Thorolfsdottir, R. B. et al. A Missense Variant in PLEC Increases Risk of Atrial Fibrillation. J. Am. Coll. Cardiol. 70, 2157–2168 (2017).
pubmed: 29050564 pmcid: 5704994 doi: 10.1016/j.jacc.2017.09.005
Consortium, G. T. et al. Genetic effects on gene expression across human tissues. Nature 550, 204–213 (2017).
doi: 10.1038/nature24277
Schmitt, A. D. et al. A compendium of chromatin contact maps reveals spatially active regions in the human genome. Cell Rep. 17, 2042–2059 (2016).
pubmed: 27851967 pmcid: 5478386 doi: 10.1016/j.celrep.2016.10.061
Nielsen, J. B. et al. Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development. Am. J. Hum. Genet 102, 103–115 (2018).
pubmed: 29290336 doi: 10.1016/j.ajhg.2017.12.003
Roselli, C. et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat. Genet. 50, 1225–1233 (2018).
pubmed: 29892015 pmcid: 6136836 doi: 10.1038/s41588-018-0133-9
Pers, T. H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
pubmed: 25597830 pmcid: 4420238 doi: 10.1038/ncomms6890
Sudlow, C. et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
pubmed: 25826379 pmcid: 4380465 doi: 10.1371/journal.pmed.1001779
Bermudez-Jimenez, F. J. et al. Novel desmin mutation p.Glu401Asp impairs filament formation, disrupts cell membrane integrity, and causes severe arrhythmogenic left ventricular cardiomyopathy/dysplasia. Circulation 137, 1595–1610 (2018).
pubmed: 29212896 doi: 10.1161/CIRCULATIONAHA.117.028719
Norgett, E. E. et al. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Hum. Mol. Genet. 9, 2761–6 (2000).
pubmed: 11063735 doi: 10.1093/hmg/9.18.2761
Rampazzo, A. et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am. J. Hum. Genet. 71, 1200–6 (2002).
pubmed: 12373648 pmcid: 385098 doi: 10.1086/344208
Taylor, M. R. et al. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation 115, 1244–51 (2007).
pubmed: 17325244 doi: 10.1161/CIRCULATIONAHA.106.646778
van Tintelen, J. P. et al. Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm 6, 1574–83 (2009).
pubmed: 19879535 doi: 10.1016/j.hrthm.2009.07.041
Glukhov, A. V. et al. Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation 125, 1835–47 (2012).
pubmed: 22412072 pmcid: 3351089 doi: 10.1161/CIRCULATIONAHA.111.047274
Gomes, J. et al. Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur. Heart J. 33, 1942–53 (2012).
pubmed: 22240500 pmcid: 3409421 doi: 10.1093/eurheartj/ehr472
Fukuzawa, A. et al. Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J. Cell Sci. 121, 1841–51 (2008).
pubmed: 18477606 doi: 10.1242/jcs.028019
Cheng, H. et al. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ. Res 107, 348–56 (2010).
pubmed: 20538684 pmcid: 3684396 doi: 10.1161/CIRCRESAHA.110.218735
Hojayev, B., Rothermel, B. A., Gillette, T. G. & Hill, J. A. FHL2 binds calcineurin and represses pathological cardiac growth. Mol. Cell Biol. 32, 4025–34 (2012).
pubmed: 22851699 pmcid: 3457523 doi: 10.1128/MCB.05948-11
Friedrich, F. W. et al. FHL2 expression and variants in hypertrophic cardiomyopathy. Basic Res. Cardiol. 109, 451 (2014).
pubmed: 25358972 pmcid: 4215105 doi: 10.1007/s00395-014-0451-8
Dierck, F. et al. The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. J. Biol. Chem. 292, 15180–15191 (2017).
pubmed: 28717008 pmcid: 5602380 doi: 10.1074/jbc.M117.786764
Duhme, N. et al. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur. Heart J. 34, 2768–75 (2013).
pubmed: 23178648 doi: 10.1093/eurheartj/ehs391
Milanesi, R., Baruscotti, M., Gnecchi-Ruscone, T. & DiFrancesco, D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N. Engl. J. Med 354, 151–7 (2006).
pubmed: 16407510 doi: 10.1056/NEJMoa052475
Milano, A. et al. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy. J. Am. Coll. Cardiol. 64, 745–56 (2014).
pubmed: 25145517 doi: 10.1016/j.jacc.2014.05.045
Priori, S. G. et al. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103, 196–200 (2001).
pubmed: 11208676 doi: 10.1161/01.CIR.103.2.196
Kubo, T. et al. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 323, 411–6 (1986).
pubmed: 3762692 doi: 10.1038/323411a0
Kurachi, Y. G protein regulation of cardiac muscarinic potassium channel. Am. J. Physiol. 269, C821–30 (1995).
pubmed: 7485449 doi: 10.1152/ajpcell.1995.269.4.C821
Aistrup, G. L. et al. Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation. Cardiovasc. Res. 83, 481–92 (2009).
pubmed: 19457892 pmcid: 2709464 doi: 10.1093/cvr/cvp148
Dobrev, D. et al. Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials. Circulation 104, 2551–7 (2001).
pubmed: 11714649 doi: 10.1161/hc4601.099466
Stavrakis, S. et al. Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves’ hyperthyroidism. J. Am. Coll. Cardiol. 54, 1309–16 (2009).
pubmed: 19778674 pmcid: 2801559 doi: 10.1016/j.jacc.2009.07.015
Winkler, T. W. et al. Quality control and conduct of genome-wide association meta-analyses. Nat. Protoc. 9, 1192–212 (2014).
pubmed: 24762786 pmcid: 4083217 doi: 10.1038/nprot.2014.071
Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–1 (2010).
pubmed: 20616382 pmcid: 2922887 doi: 10.1093/bioinformatics/btq340
Higgins, J. P., Thompson, S. G., Deeks, J. J. & Altman, D. G. Measuring inconsistency in meta-analyses. BMJ 327, 557–60 (2003).
pubmed: 12958120 pmcid: 12958120 doi: 10.1136/bmj.327.7414.557
Pruim, R. J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336–7 (2010).
pubmed: 20634204 pmcid: 2935401 doi: 10.1093/bioinformatics/btq419
Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet 88, 76–82 (2011).
pubmed: 21167468 pmcid: 3014363 doi: 10.1016/j.ajhg.2010.11.011
Loh, P. R. et al. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat. Genet. 47, 1385–92 (2015).
pubmed: 26523775 pmcid: 4666835 doi: 10.1038/ng.3431
McLaren, W. et al. The ensembl variant effect predictor. Genome Biol. 17, 122 (2016).
pubmed: 27268795 pmcid: 4893825 doi: 10.1186/s13059-016-0974-4
Kumar, P., Henikoff, S. & Ng, P. C. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073–81 (2009).
doi: 10.1038/nprot.2009.86 pubmed: 19561590
Adzhubei, I., Jordan, D. M. & Sunyaev, S. R. Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet Chapter 7, Unit7 20 (2013).
Bernstein, B. E. et al. The NIH roadmap epigenomics mapping consortium. Nat. Biotechnol. 28, 1045–8 (2010).
pubmed: 20944595 pmcid: 3607281 doi: 10.1038/nbt1010-1045
Ward, L. D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930–4 (2012).
pubmed: 22064851 pmcid: 22064851 doi: 10.1093/nar/gkr917
Barbeira, A. N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat. Commun. 9, 1825 (2018).
pubmed: 29739930 pmcid: 5940825 doi: 10.1038/s41467-018-03621-1
Iotchkova, V. et al. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals. Nat. Genet. 51, 343–353 (2019).
pubmed: 30692680 pmcid: 6908448 doi: 10.1038/s41588-018-0322-6
Consortium, E. P. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).
doi: 10.1038/nature11247
Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res 47, D1005–D1012 (2019).
pubmed: 30445434 doi: 10.1093/nar/gky1120
Staley, J. R. et al. PhenoScanner: a database of human genotype-phenotype associations. Bioinformatics 32, 3207–3209 (2016).
pubmed: 27318201 pmcid: 5048068 doi: 10.1093/bioinformatics/btw373
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–75 (2007).
pubmed: 17701901 pmcid: 1950838 doi: 10.1086/519795

Auteurs

Ioanna Ntalla (I)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Lu-Chen Weng (LC)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-1475-4930

James H Cartwright (JH)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Amelia Weber Hall (AW)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-7915-0313

Gardar Sveinbjornsson (G)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.

Nathan R Tucker (NR)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-5071-4218

Seung Hoan Choi (SH)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Mark D Chaffin (MD)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-1234-5562

Carolina Roselli (C)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-5267-6756

Michael R Barnes (MR)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.
ORCID: 0000-0001-9097-7381

Borbala Mifsud (B)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar.
ORCID: 0000-0003-3429-3094

Helen R Warren (HR)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.

Caroline Hayward (C)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-9405-9550

Jonathan Marten (J)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

James J Cranley (JJ)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Maria Pina Concas (MP)

Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
ORCID: 0000-0003-3598-2537

Paolo Gasparini (P)

Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Department of Medicine, Surgery and Health Science, University of Trieste, Trieste, Italy.

Thibaud Boutin (T)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0003-4754-1675

Ivana Kolcic (I)

University of Split School of Medicine, Split, Croatia.
ORCID: 0000-0001-7918-6052

Ozren Polasek (O)

University of Split School of Medicine, Split, Croatia.
Clinical Hospital Centre Split, Split, Croatia.
Psychiatric Hospital Sveti Ivan, Zagreb, Croatia.

Igor Rudan (I)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6993-6884

Nathalia M Araujo (NM)

Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Maria Fernanda Lima-Costa (MF)

Rene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.

Antonio Luiz P Ribeiro (ALP)

Hospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Renan P Souza (RP)

Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
ORCID: 0000-0002-9479-4432

Eduardo Tarazona-Santos (E)

Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Vilmantas Giedraitis (V)

Department of Public Health, Geriatrics, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-3423-2021

Erik Ingelsson (E)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-2256-6972

Anubha Mahajan (A)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
ORCID: 0000-0001-5585-3420

Andrew P Morris (AP)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Biostatistics, University of Liverpool, Liverpool, UK.
Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.
ORCID: 0000-0002-6805-6014

Fabiola Del Greco M (F)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Luisa Foco (L)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Martin Gögele (M)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Andrew A Hicks (AA)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
ORCID: 0000-0001-6320-0411

James P Cook (JP)

Department of Biostatistics, University of Liverpool, Liverpool, UK.

Lars Lind (L)

Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.

Cecilia M Lindgren (CM)

Nuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.
Nuffield Department of Medicine, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Johan Sundström (J)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-2247-8454

Christopher P Nelson (CP)

Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK.
ORCID: 0000-0001-8025-2897

Muhammad B Riaz (MB)

Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK.
ORCID: 0000-0002-5512-1745

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK.

Gianfranco Sinagra (G)

Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, Italy.
ORCID: 0000-0003-2700-8478

Sheila Ulivi (S)

Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.

Mika Kähönen (M)

Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Department of Clinical Physiology, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center Tampere University, Tampere, Finland.

Pashupati P Mishra (PP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland.
ORCID: 0000-0001-5177-3431

Nina Mononen (N)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland.

Kjell Nikus (K)

Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Department of Cardiology, Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Mark J Caulfield (MJ)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.
ORCID: 0000-0001-9295-3594

Anna Dominiczak (A)

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
ORCID: 0000-0003-4913-3608

Sandosh Padmanabhan (S)

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

May E Montasser (ME)

Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Jeff R O'Connell (JR)

Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Kathleen Ryan (K)

Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Alan R Shuldiner (AR)

Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Stefanie Aeschbacher (S)

Cardiology Division, University Hospital, Basel, Switzerland.

David Conen (D)

Cardiology Division, University Hospital, Basel, Switzerland.
Population Health Research Institute, McMaster University, Hamilton, ON, Canada.

Lorenz Risch (L)

Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.
Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein.
Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
ORCID: 0000-0003-2692-6699

Sébastien Thériault (S)

Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, QC, Canada.

Nina Hutri-Kähönen (N)

Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland.

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland.
Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.

Olli T Raitakari (OT)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Catriona L K Barnes (CLK)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Harry Campbell (H)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-6361-5059

James F Wilson (JF)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5751-9178

Aaron Isaacs (A)

CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University, Maastricht, The Netherlands.
ORCID: 0000-0001-5037-4834

Jan A Kors (JA)

Department of Medical Informatics Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Cornelia M van Duijn (CM)

Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0002-2374-9204

Paul L Huang (PL)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Vilmundur Gudnason (V)

Icelandic Heart Association, Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0001-5696-0084

Tamara B Harris (TB)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA.

Lenore J Launer (LJ)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA.

Albert V Smith (AV)

Icelandic Heart Association, Kopavogur, Iceland.
School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0003-1942-5845

Erwin P Bottinger (EP)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8532-5087

Girish N Nadkarni (GN)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Michael H Preuss (MH)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-5266-8465

Adolfo Correa (A)

Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
ORCID: 0000-0002-9501-600X

Hao Mei (H)

Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.

James Wilson (J)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

Thomas Meitinger (T)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Martina Müller-Nurasyid (M)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
ORCID: 0000-0003-3793-5910

Annette Peters (A)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
German Center for Diabetes Research, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.

Melanie Waldenberger (M)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
ORCID: 0000-0003-0583-5093

Massimo Mangino (M)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
ORCID: 0000-0002-2167-7470

Timothy D Spector (TD)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.

Michiel Rienstra (M)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-2581-070X

Yordi J van de Vegte (YJ)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pim van der Harst (P)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-2713-686X

Niek Verweij (N)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Genomics plc, Oxford, UK.
ORCID: 0000-0002-4303-7685

Stefan Kääb (S)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.

Katharina Schramm (K)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.

Moritz F Sinner (MF)

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.

Konstantin Strauch (K)

Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
IBE, Faculty of Medicine, LMU Munich, Munich, Germany.

Michael J Cutler (MJ)

Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.

Diane Fatkin (D)

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Cardiology Department, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, Australia.
ORCID: 0000-0002-9010-9856

Barry London (B)

Department of Cardiovascular Medicine, University of Iowa, Iowa City, IA, USA.

Morten Olesen (M)

Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Dan M Roden (DM)

Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

M Benjamin Shoemaker (M)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

J Gustav Smith (J)

Department of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital, Lund, Sweden.

Mary L Biggs (ML)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Joshua C Bis (JC)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.

Jennifer A Brody (JA)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-8509-148X

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Kenneth Rice (K)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3071-7278

Nona Sotoodehnia (N)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Cardiology Division, University of Washington, Seattle, WA, USA.

Alessandro De Grandi (A)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Christian Fuchsberger (C)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Cristian Pattaro (C)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
ORCID: 0000-0002-4119-0109

Peter P Pramstaller (PP)

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

Ian Ford (I)

Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.

J Wouter Jukema (J)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
ORCID: 0000-0002-3246-8359

Peter W Macfarlane (PW)

Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Stella Trompet (S)

Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Marcus Dörr (M)

DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany.

Stephan B Felix (SB)

DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany.

Uwe Völker (U)

DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, Germany.

Stefan Weiss (S)

DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, Germany.
ORCID: 0000-0002-3553-4315

Aki S Havulinna (AS)

Finnish Institute for Health and Welfare, Helsinki, Finland.
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4787-8959

Antti Jula (A)

Finnish Institute for Health and Welfare, Helsinki, Finland.

Katri Sääksjärvi (K)

Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0002-5061-4911

Veikko Salomaa (V)

Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0001-7563-5324

Xiuqing Guo (X)

Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Susan R Heckbert (SR)

Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.

Henry J Lin (HJ)

Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Jerome I Rotter (JI)

Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Kent D Taylor (KD)

Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0002-2756-4370

Jie Yao (J)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Renée de Mutsert (R)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Arie C Maan (AC)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Dennis O Mook-Kanamori (DO)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.

Raymond Noordam (R)

Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Francesco Cucca (F)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Jun Ding (J)

Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.

Edward G Lakatta (EG)

Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA.
ORCID: 0000-0002-4772-0035

Yong Qian (Y)

Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.

Kirill V Tarasov (KV)

Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA.

Daniel Levy (D)

Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

Honghuang Lin (H)

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
ORCID: 0000-0003-3043-3942

Christopher H Newton-Cheh (CH)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.

Kathryn L Lunetta (KL)

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-9268-810X

Alison D Murray (AD)

The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
ORCID: 0000-0003-4915-4847

David J Porteous (DJ)

Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0003-1249-6106

Blair H Smith (BH)

Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
ORCID: 0000-0002-5362-9430

Bruno H Stricker (BH)

Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

André Uitterlinden (A)

Human Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0002-7276-3387

Marten E van den Berg (ME)

Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Jeffrey Haessler (J)

Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.

Rebecca D Jackson (RD)

Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA.

Charles Kooperberg (C)

Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.

Ulrike Peters (U)

Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
ORCID: 0000-0001-5666-9318

Alexander P Reiner (AP)

Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Eric A Whitsel (EA)

Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USA.

Alvaro Alonso (A)

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
ORCID: 0000-0002-2225-8323

Dan E Arking (DE)

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Eric Boerwinkle (E)

Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.

Georg B Ehret (GB)

Cardiology, Geneva University Hospitals, Geneva, Switzerland.
ORCID: 0000-0002-5730-0675

Elsayed Z Soliman (EZ)

Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
ORCID: 0000-0001-5632-8150

Christy L Avery (CL)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.

Stephanie M Gogarten (SM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-7231-9745

Kathleen F Kerr (KF)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-6438-9583

Cathy C Laurie (CC)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Amanda A Seyerle (AA)

Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA.

Adrienne Stilp (A)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Solmaz Assa (S)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

M Abdullah Said (M)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0003-2920-7745

M Yldau van der Ende (M)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pier D Lambiase (PD)

Barts Heart Centre, St Bartholomews Hospital, London, UK.
Institute of Cardiovascular Science, University College London, London, UK.

Michele Orini (M)

Barts Heart Centre, St Bartholomews Hospital, London, UK.
Department of Mechanical Engineering, University College London, London, UK.
ORCID: 0000-0001-5773-0344

Julia Ramirez (J)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Institute of Cardiovascular Science, University College London, London, UK.
ORCID: 0000-0003-4130-5866

Stefan Van Duijvenboden (S)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Institute of Cardiovascular Science, University College London, London, UK.
ORCID: 0000-0001-8897-558X

David O Arnar (DO)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland.

Daniel F Gudbjartsson (DF)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0002-5222-9857

Hilma Holm (H)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.

Patrick Sulem (P)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
ORCID: 0000-0001-7123-6123

Gudmar Thorleifsson (G)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.

Rosa B Thorolfsdottir (RB)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0001-7475-0398

Unnur Thorsteinsdottir (U)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Emelia J Benjamin (EJ)

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Section of Cardiovascular Medicine and Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0003-4076-2336

Andrew Tinker (A)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.

Kari Stefansson (K)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0003-1676-864X

Patrick T Ellinor (PT)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-2067-0533

Yalda Jamshidi (Y)

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London, London, UK.
ORCID: 0000-0003-0151-6482

Steven A Lubitz (SA)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. slubitz@mgh.harvard.edu.
Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu.
ORCID: 0000-0002-9599-4866

Patricia B Munroe (PB)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.
National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.
ORCID: 0000-0002-4176-2947

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Multi-ancestry GWAS of the...
questionsmedicales.fr › Maladies cardiovasculaires › Multi-ancestry GWAS of the...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocardiographie › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Endophénotypes › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Multi-ancestry GWAS of the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Multi-ancestry GWAS of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Multi-ancestry GWAS of the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Multi-ancestry GWAS of the...