Placental Pathology in COVID-19.
COVID-19
Coronavirus
Decidual arteriopathy
Intervillous thrombi
Maternal vascular malperfusion
Maternal vascular underperfusion
Perinatal outcomes
Placental pathology
SARS-CoV-2
Journal
American journal of clinical pathology
ISSN: 1943-7722
Titre abrégé: Am J Clin Pathol
Pays: England
ID NLM: 0370470
Informations de publication
Date de publication:
08 06 2020
08 06 2020
Historique:
pubmed:
23
5
2020
medline:
17
6
2020
entrez:
23
5
2020
Statut:
ppublish
Résumé
To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy. Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Sixteen placentas from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were examined (15 with live birth in the third trimester, 1 delivered in the second trimester after intrauterine fetal demise). Compared to controls, third trimester placentas were significantly more likely to show at least one feature of maternal vascular malperfusion (MVM), particularly abnormal or injured maternal vessels, and intervillous thrombi. Rates of acute and chronic inflammation were not increased.The placenta from the patient with intrauterine fetal demise showed villous edema and a retroplacental hematoma. Relative to controls, COVID-19 placentas show increased prevalence of decidual arteriopathy and other features of MVM, a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. Only 1 COVID-19 patient was hypertensive despite the association of MVM with hypertensive disorders and preeclampsia. These changes may reflect a systemic inflammatory or hypercoagulable state influencing placental physiology.
Identifiants
pubmed: 32441303
pii: 5842018
doi: 10.1093/ajcp/aqaa089
pmc: PMC7279066
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-32Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
Type : CommentIn
Informations de copyright
© American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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