Neuronal
Animals
Cell Line, Tumor
Cells, Cultured
DNA (Cytosine-5-)-Methyltransferase 1
/ metabolism
Epigenesis, Genetic
Gene Expression Regulation, Developmental
Histone Code
Interneurons
/ metabolism
LIM-Homeodomain Proteins
/ genetics
Mice
Mice, Inbred C57BL
Preoptic Area
/ cytology
Transcription Factors
/ genetics
DNMT1
Interneuron development
LHX1
epigenetic network
histone acetylation
histone methylation
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
23
5
2020
medline:
16
6
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Apart from the conventional view of repressive promoter methylation, the DNA methyltransferase 1 (DNMT1) was recently described to modulate gene expression through a variety of interactions with diverse epigenetic key players. We here investigated the DNMT1-dependent transcriptional control of the homeobox transcription factor LHX1, which we previously identified as an important regulator in cortical interneuron development. We found that LHX1 expression in embryonic interneurons originating in the embryonic pre-optic area (POA) is regulated by non-canonic DNMT1 function. Analysis of histone methylation and acetylation revealed that both epigenetic modifications seem to be implicated in the control of
Identifiants
pubmed: 32441560
doi: 10.1080/15592294.2020.1767372
pmc: PMC7595593
doi:
Substances chimiques
LIM-Homeodomain Proteins
0
Lhx1 protein, mouse
0
Transcription Factors
0
DNA (Cytosine-5-)-Methyltransferase 1
EC 2.1.1.37
Dnmt1 protein, mouse
EC 2.1.1.37
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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