Danger-associated metabolic modifications during bacterial infection of macrophages.
DAMM
OXPHOS
glycolysis
immunometabolism
intracellular bacteria
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
12
03
2020
accepted:
15
05
2020
pubmed:
23
5
2020
medline:
30
12
2020
entrez:
23
5
2020
Statut:
ppublish
Résumé
In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism.
Identifiants
pubmed: 32441740
pii: 5842096
doi: 10.1093/intimm/dxaa035
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-483Informations de copyright
© The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.