Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease.
Alzheimer's disease
blood brain barrier
calcium
dantrolene
intranasal
treatment.
Journal
Current Alzheimer research
ISSN: 1875-5828
Titre abrégé: Curr Alzheimer Res
Pays: United Arab Emirates
ID NLM: 101208441
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
06
2019
revised:
24
02
2020
accepted:
11
05
2020
pubmed:
23
5
2020
medline:
5
8
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnormal release of Ca2+ via over activated ryanodine receptor (RyR), has been increasingly considered as an alternative upstream mechanism in AD pathology. Consequently, dantrolene, a RyR antagonist and FDA approved drug to treat malignant hyperthermia and chronic muscle spasms, has been shown to ameliorate memory loss in AD transgenic mice. However, the inefficiency of dantrolene to pass the Blood Brain Barrier (BBB) and penetrate the Central Nervous System needs to be resolved, considering its dose-dependent neuroprotection in AD and other neurodegenerative diseases. In this mini-review, we will discuss the current status of dantrolene neuroprotection in AD treatment and a strategy to maximize its beneficial effects, such as intranasal administration of dantrolene.
Identifiants
pubmed: 32442084
pii: CAR-EPUB-106843
doi: 10.2174/1567205017666200522204722
pmc: PMC7705762
mid: NIHMS1649301
doi:
Substances chimiques
Calcium Channel Blockers
0
Neuroprotective Agents
0
Ryanodine Receptor Calcium Release Channel
0
Dantrolene
F64QU97QCR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
324-328Subventions
Organisme : NIA NIH HHS
ID : R01 AG061447
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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