Proteomic applications in pathology and laboratory medicine: Present state and future prospects.
Chemistry, Clinical
/ methods
Chromatography, Liquid
/ methods
Diagnostic Tests, Routine
/ methods
Drug Monitoring
/ methods
Forecasting
Humans
Immunoprecipitation
/ methods
Microbiological Techniques
Pathology
/ methods
Proteomics
/ methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/ methods
Tandem Mass Spectrometry
/ methods
Biomarker
Imaging mass spectrometry
Laboratory
MALDI-TOF
Mass spectrometry
Medicine
Microbiology
Proteomics
Journal
Clinical biochemistry
ISSN: 1873-2933
Titre abrégé: Clin Biochem
Pays: United States
ID NLM: 0133660
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
20
01
2020
revised:
13
05
2020
accepted:
13
05
2020
pubmed:
23
5
2020
medline:
20
1
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Clinical mass spectrometry applications have traditionally focused on small molecules, particularly in the areas of therapeutic drug monitoring, toxicology, and measurement of endogenous and exogenous steroids. More recently, the use of matrix assisted laser desorption/ionization time of flight mass spectrometry for the identification of microbial pathogens has been widely implemented. Following this evolution, there has been an expanding role for the measurement of peptides and proteins in pathology and laboratory medicine. This review explores the current state of protein measurement by clinical mass spectrometry and the analytical strategies employed, as well as emerging applications in clinical chemistry, clinical microbiology and anatomical pathology.
Identifiants
pubmed: 32442429
pii: S0009-9120(20)30081-3
doi: 10.1016/j.clinbiochem.2020.05.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-20Informations de copyright
Copyright © 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.