Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy.
analytical treatment interruption
antiretroviral therapy
human immunodeficiency virus
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
13 10 2020
13 10 2020
Historique:
received:
19
03
2020
accepted:
20
05
2020
pubmed:
23
5
2020
medline:
12
3
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Historical data regarding time to viral rebound following analytical treatment interruption (ATI) have been used to determine therapeutic efficacy in HIV cure trials; however, such data were collected from studies conducted a decade or more ago and included participants receiving older antiretroviral therapy (ART) regimens with infrequent virologic monitoring. We conducted a study of 22 HIV-infected participants receiving modern ART to determine the kinetics of plasma viral rebound following ATI. Our data suggest that modern ART does not alter kinetics of viral rebound when compared to previous regimens and that immunologic interventions may be necessary to achieve ART-free virologic remission. Clinical Trials Registration ClinicaTrials.gov identifier: NCT03225118.
Identifiants
pubmed: 32443148
pii: 5842227
doi: 10.1093/infdis/jiaa270
pmc: PMC7751567
doi:
Substances chimiques
Anti-Retroviral Agents
0
Banques de données
ClinicalTrials.gov
['NCT03225118']
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1655-1659Informations de copyright
Published by Oxford University Press for the Infectious Diseases Society of America 2020.
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