The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice.
Smpd1
acid sphingomyelinase
anxiety-like behavior
ceramide
depressive-like behavior
forebrain
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 05 2020
18 05 2020
Historique:
received:
29
04
2020
revised:
14
05
2020
accepted:
15
05
2020
entrez:
24
5
2020
pubmed:
24
5
2020
medline:
25
2
2021
Statut:
epublish
Résumé
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tg
Identifiants
pubmed: 32443534
pii: cells9051244
doi: 10.3390/cells9051244
pmc: PMC7290754
pii:
doi:
Substances chimiques
Ceramides
0
RNA, Messenger
0
Sphingolipids
0
acid sphingomyelinase-1
EC 3.1.4.-
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
FEBS Lett. 2002 Oct 30;531(1):38-46
pubmed: 12401200
Addict Biol. 2019 Dec 11;:e12847
pubmed: 31828921
Transl Psychiatry. 2019 Apr 26;9(1):144
pubmed: 31028243
Cancer Res. 2017 Nov 1;77(21):5963-5976
pubmed: 28883000
PLoS Genet. 2017 Mar 27;13(3):e1006684
pubmed: 28346493
Prog Brain Res. 2008;170:291-303
pubmed: 18655890
Adv Enzyme Regul. 2011;51(1):51-8
pubmed: 21035485
Mol Psychiatry. 2018 Dec;23(12):2324-2346
pubmed: 30038230
PLoS One. 2016 Sep 06;11(9):e0162498
pubmed: 27598773
J Neurosci. 2002 Aug 1;22(15):6309-14
pubmed: 12151506
Behav Brain Res. 2005 Jan 6;156(1):105-14
pubmed: 15474655
Adv Enzyme Regul. 2010;50(1):349-62
pubmed: 19914275
Cell Mol Life Sci. 2007 Sep;64(17):2270-84
pubmed: 17558466
EMBO J. 1992 Jul;11(7):2541-50
pubmed: 1352754
J Biol Chem. 2003 Aug 8;278(32):29948-53
pubmed: 12764132
J Biol Chem. 2012 Mar 16;287(12):9128-36
pubmed: 22291021
Sci Rep. 2016 Nov 24;6:37064
pubmed: 27883090
Brain Behav. 2017 Sep 26;7(11):e00836
pubmed: 29201542
Cell Death Differ. 2011 Aug;18(8):1356-65
pubmed: 21331079
J Biol Chem. 2007 Apr 13;282(15):11386-96
pubmed: 17244618
Front Psychiatry. 2018 Oct 16;9:496
pubmed: 30386262
N Engl J Med. 2008 Jan 3;358(1):55-68
pubmed: 18172175
J Psychiatr Res. 2013 Mar;47(3):357-62
pubmed: 23207112
J Neuropsychiatry Clin Neurosci. 2011 Spring;23(2):215-8
pubmed: 21677254
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Metabolism. 2019 Jun;95:65-76
pubmed: 30954559
J Biol Chem. 2007 Jan 12;282(2):1305-12
pubmed: 17105727
J Chromatogr A. 2017 Jan 20;1481:137-144
pubmed: 28012590
Anal Bioanal Chem. 2016 Sep;408(23):6497-507
pubmed: 27457104
Mol Psychiatry. 2016 Jan;21(1):80-8
pubmed: 25754084
Psychopharmacology (Berl). 2018 Oct;235(10):3017-3030
pubmed: 30116859
Acta Neuropathol. 2017 Mar;133(3):463-483
pubmed: 28000031
Neurobiol Stress. 2016 Aug 24;6:78-93
pubmed: 28229111
J Lipid Res. 1967 May;8(3):202-9
pubmed: 4962590
Nat Med. 2013 Jul;19(7):934-8
pubmed: 23770692
J Neural Transm (Vienna). 2005 Nov;112(11):1583-90
pubmed: 16245071
J Biol Chem. 2009 Apr 24;284(17):11346-53
pubmed: 19251691