Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications.
adipokines
diabetic foot
inflammation
metabolic disorders
obesity
psoriasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 May 2020
18 May 2020
Historique:
received:
14
04
2020
revised:
14
05
2020
accepted:
15
05
2020
entrez:
24
5
2020
pubmed:
24
5
2020
medline:
26
2
2021
Statut:
epublish
Résumé
The World Health Organization (WHO) has recognized obesity as one of the top ten threats to human health. It is estimated that the number of obese and overweight people worldwide exceeds the number of those who are undernourished. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of increased release of biologically active adipokines. Adipokines released into the circulating blood, due to their specific receptors on the surface of target cells, act as classic hormones affecting the metabolism of tissues and organs. What is more, adipokines and cytokines may decrease the insulin sensitivity of tissues and induce inflammation and development of chronic complications. Certainly, it can be stated that in an era of a global obesity pandemic, adipokines may gain more and more importance as regards their use in the diagnostic evaluation and treatment of diseases. An extensive search for materials on the role of white, brown and perivascular fatty tissue and obesity-related metabolic and chronic complications was conducted online using PubMed, the Cochrane database and Embase.
Identifiants
pubmed: 32443588
pii: ijms21103570
doi: 10.3390/ijms21103570
pmc: PMC7278967
pii:
doi:
Substances chimiques
Adipokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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