Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression.
Animals
Carcinoma, Basal Cell
/ diagnosis
Disease Models, Animal
Ectopic Gene Expression
Epidermis
/ pathology
Gene Expression Regulation, Neoplastic
Hedgehog Proteins
/ metabolism
Humans
Mice
Mice, Transgenic
Mutation
Patched-1 Receptor
/ genetics
Receptors, Notch
/ metabolism
SOXF Transcription Factors
/ genetics
Severity of Illness Index
Signal Transduction
/ genetics
Skin Neoplasms
/ diagnosis
Basal cell carcinoma
Hedgehog
Notch
Patched1
Sox18
Journal
Journal of dermatological science
ISSN: 1873-569X
Titre abrégé: J Dermatol Sci
Pays: Netherlands
ID NLM: 9011485
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
27
11
2019
revised:
14
04
2020
accepted:
16
04
2020
pubmed:
24
5
2020
medline:
15
4
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Basal Cell Carcinoma is the most common tumour and yet much remains to be determined regarding the molecular mechanisms that leads to its development. Hedgehog signal activation is sufficient for BCC induction, but the molecular mediators of BCC growth are not well understood. SoxF transcription factor Sox18 has been identified in human BCC, but its role in growth of the tumour is as yet unknown. To determine if Sox18 is involved in the regulation of Basal Cell Carcinoma growth. We analysed the function of Sox18 by combining a dominant negative Sox18 mouse model, Sox18 These data suggest that Sox18 is a hedgehog regulated mediator of tumour suppression within Basal Cell Carcinoma epidermis.
Sections du résumé
BACKGROUND
BACKGROUND
Basal Cell Carcinoma is the most common tumour and yet much remains to be determined regarding the molecular mechanisms that leads to its development. Hedgehog signal activation is sufficient for BCC induction, but the molecular mediators of BCC growth are not well understood. SoxF transcription factor Sox18 has been identified in human BCC, but its role in growth of the tumour is as yet unknown.
OBJECTIVE
OBJECTIVE
To determine if Sox18 is involved in the regulation of Basal Cell Carcinoma growth.
METHODS
METHODS
We analysed the function of Sox18 by combining a dominant negative Sox18 mouse model, Sox18
CONCLUSIONS
CONCLUSIONS
These data suggest that Sox18 is a hedgehog regulated mediator of tumour suppression within Basal Cell Carcinoma epidermis.
Identifiants
pubmed: 32444239
pii: S0923-1811(20)30142-0
doi: 10.1016/j.jdermsci.2020.04.006
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Patched-1 Receptor
0
Ptch1 protein, mouse
0
Receptors, Notch
0
SOXF Transcription Factors
0
Sox18 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-185Informations de copyright
Copyright © 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The Authors have no Conflict of Interest to declare.