Coexistence of Von Willebrand disease and gastrointestinal stromal tumor (G.I.S.T): Case report of a rare and challenge association.
Gastrointestinal bleeding
Gastrointestinal stromal tumor (GIST)
Thrombotic risk
Von Willebrand 2B
Journal
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
ISSN: 1473-0502
Titre abrégé: Transfus Apher Sci
Pays: England
ID NLM: 101095653
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
09
12
2019
revised:
08
04
2020
accepted:
19
04
2020
pubmed:
24
5
2020
medline:
9
6
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is caused by a quantitative (type 1 and 3) or qualitative (type 2) defect of Von Willebrand factor (VWF). Bleeding from the gastrointestinal (GI) tract is not uncommon in VWD and is usually associated with angiodysplasia. We report herein on the management of a patient affected by VWD2B with severe GI bleeding secondary to gastrointestinal stromal tumor (GIST) complicated by deep vein thrombosis (DVT). The current case demonstrated that the hemostatic balance, in RBDs under specific circumstances, can range from a tendency toward a hemorrhagic to normal or prothrombotic state. In these patients, a close collaboration between hematologists and surgeons can guarantee appropriate management in high-risk clinical scenarios.
Identifiants
pubmed: 32444278
pii: S1473-0502(20)30100-2
doi: 10.1016/j.transci.2020.102805
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Pagination
102805Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.