Targeted PET Imaging of Chemokine Receptor 2-Positive Monocytes and Macrophages in the Injured Heart.

Animals Heart Injuries / diagnostic imaging Isotope Labeling Mice Mice, Inbred C57BL Monocytes / metabolism Phenprocoumon / metabolism Positron-Emission Tomography Receptors, CCR2 / metabolism
C-C chemokine receptor type 2 (CCR2) PET heart injury macrophages monocytes

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
01 2021
Historique:
received: 06 03 2020
accepted: 16 04 2020
pubmed: 24 5 2020
medline: 27 4 2021
entrez: 24 5 2020
Statut: ppublish

Résumé

Proinflammatory macrophages are important mediators of inflammation after myocardial infarction and of allograft injury after heart transplantation. The aim of this study was to image the recruitment of proinflammatory chemokine receptor 2-positive (CCR2+) cells in multiple heart injury models.

Identifiants

DOI: 10.2967/jnumed.120.244673 PMID: 32444372 PMC: PMC9364878
pubmed: 32444372
pii: jnumed.120.244673
doi: 10.2967/jnumed.120.244673
pmc: PMC9364878
doi:

Substances chimiques

CCR2 protein, human 0
Receptors, CCR2 0
Phenprocoumon Q08SIO485D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

111-114

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL145212
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB025815
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131908
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL123519
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL094601
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138466
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139714
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI116501
Pays : United States

Informations de copyright

© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Références

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pubmed: 27273836
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pubmed: 29567678
Circ Res. 2019 Mar 15;124(6):881-890
pubmed: 30661445
JACC Cardiovasc Imaging. 2015 Dec;8(12):1417-1426
pubmed: 26577262
Circ Res. 2019 Jan 18;124(2):263-278
pubmed: 30582448
J Clin Invest. 2012 Jul;122(7):2499-508
pubmed: 22706307
JCI Insight. 2016 Aug 4;1(12):
pubmed: 27536731
Radiology. 2017 Jun;283(3):758-768
pubmed: 28045644
Nat Med. 2018 Aug;24(8):1234-1245
pubmed: 29892064
J Nucl Med. 2019 Dec;60(12):1743-1749
pubmed: 31405922
J Nucl Med. 2020 Jul;61(7):977-980
pubmed: 31806766
Nat Biotechnol. 2011 Oct 09;29(11):1005-10
pubmed: 21983520

Auteurs

Gyu Seong Heo (GS)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Geetika Bajpai (G)

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

Wenjun Li (W)

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Hannah P Luehmann (HP)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Deborah H Sultan (DH)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Hao Dun (H)

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

Florian Leuschner (F)

Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.

Steven L Brody (SL)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

Robert J Gropler (RJ)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Daniel Kreisel (D)

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.
Department of Immunology and Pathology, Washington University School of Medicine, St. Louis, Missouri; and.

Kory J Lavine (KJ)

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.
Department of Immunology and Pathology, Washington University School of Medicine, St. Louis, Missouri; and.
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri.

Yongjian Liu (Y)

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Plaies et blessures › Blessures du thorax › Lésions traumatiques du coeur › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › 4-Hydroxycoumarines › Phenprocoumone › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Targeted PET Imaging of Chemokine Receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Récepteurs CCR2 › Targeted PET Imaging of Chemokine Receptor...