Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization.
Profilin1 (PFN1)
actin
angiogenesis
cytoskeleton
diabetic retinopathy
filopodia
oxygen-induced retinopathy (OIR)
profilin
retina
tip cells
vascular endothelial cells (VECs)
vascularization
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
10
01
2020
revised:
20
05
2020
pubmed:
24
5
2020
medline:
14
1
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Angiogenesis-mediated neovascularization in the eye is usually associated with visual complications. Pathological angiogenesis is particularly prominent in the retina in the settings of proliferative diabetic retinopathy, in which it can lead to permanent loss of vision. In this study, by bioinformatics analyses, we provide evidence for elevated expression of actin-binding protein PFN1 (profilin1) in the retinal vascular endothelial cells (VECs) of individuals with proliferative diabetic retinopathy, findings further supported by gene expression analyses for PFN1 in experimentally induced abnormal retinal neovascularization in an oxygen-induced retinopathy murine model. We observed that in a conditional knockout mouse model, postnatal deletion of the
Identifiants
pubmed: 32444495
pii: S0021-9258(17)48978-2
doi: 10.1074/jbc.RA120.012613
pmc: PMC7363146
doi:
Substances chimiques
Pfn1 protein, mouse
0
Profilins
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9618-9629Subventions
Organisme : NIH HHS
ID : S10 OD019973
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL129964
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108340
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL076124
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA108607
Pays : United States
Informations de copyright
© 2020 Gau et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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