Curcumin Encapsulated Lecithin Nanoemulsions: An Oral Platform for Ultrasound Mediated Spatiotemporal Delivery of Curcumin to the Tumor.
Administration, Oral
Animals
Antineoplastic Agents
/ administration & dosage
Apoptosis
Breast Neoplasms
/ drug therapy
Cell Proliferation
Curcumin
/ administration & dosage
Drug Delivery Systems
Female
Humans
Lecithins
/ chemistry
Melanoma, Experimental
/ drug therapy
Mice
Mice, Inbred C57BL
Micelles
Nanotechnology
Rats
Rats, Wistar
Spatio-Temporal Analysis
Tissue Distribution
Tumor Cells, Cultured
Ultrasonography
/ methods
Xenograft Model Antitumor Assays
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 05 2020
22 05 2020
Historique:
received:
29
08
2019
accepted:
07
04
2020
entrez:
24
5
2020
pubmed:
24
5
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Systemic toxicity caused by conventional chemotherapy is often regarded as one of the major challenges in the treatment of cancer. Over years, the trigger-based modality has gained much attention as it holds the spatiotemporal control over release and internalization of the drug. In this article, we are reporting an increase in the anti-tumor efficacy of curcumin due to ultrasound pulses. MDA MB 231 breast cancer and B16F10 melanoma cells were incubated with lecithin-based curcumin encapsulated nanoemulsions and exposed to ultrasound in the presence and absence of microbubble. Ultrasound induced sonoporation enhanced the cytotoxicity of curcumin in MDA MB 231 and B16F10 cancer cells in the presence of microbubble by 100- and 64-fold, respectively. To study the spatiotemporal delivery of curcumin, we developed B16F10 melanoma subcutaneous tumor on both the flanks of C57BL/6 mice but only the right tumor was exposed to ultrasound. Insonation of the right tumor spatially enhanced the cytotoxicity and enabled the substantial regression of the right tumor compared to the unexposed left tumor which grew continuously in size. This study showed that the ultrasound has the potential to target and increase the drug's throughput to the tumor and enable effective treatment.
Identifiants
pubmed: 32444829
doi: 10.1038/s41598-020-65468-1
pii: 10.1038/s41598-020-65468-1
pmc: PMC7244714
doi:
Substances chimiques
Antineoplastic Agents
0
Lecithins
0
Micelles
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8587Références
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