Plumbagin promotes mitochondrial mediated apoptosis in gefitinib sensitive and resistant A549 lung cancer cell line through enhancing reactive oxygen species generation.
A549 Cells
/ drug effects
Apoptosis
/ drug effects
Cell Cycle
/ drug effects
Cell Cycle Checkpoints
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Gefitinib
/ pharmacology
Humans
Lung Neoplasms
/ drug therapy
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Naphthoquinones
/ metabolism
Reactive Oxygen Species
/ metabolism
Apoptosis
Drug resistance
Lung cancer
Mitochondrial membrane potential
Plumbagin
Reactive oxygen species
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
29
01
2020
accepted:
25
04
2020
pubmed:
24
5
2020
medline:
17
2
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Plumbagin (PL) is a natural naphthoquinone compound, isolated from Plumbago zeylanica that has cytotoxic and antimigratory potential in many cancer. However, the cytotoxic mechanism of plumbagin in drug resistant lung cancer is poorly understood. To reveal the mechanism, we studied the anticancer effect of plumbagin in both gefitinib-sensitive and resistant A549 lung cancer cells. The anticancer potential of PL was demonstrated by MTT assay and the result suggested that PL showed cytotoxicity in both gefitinib-sensitive (A549) and gefitinib-resistant (A549GR) lung cancer cells. IC
Identifiants
pubmed: 32444975
doi: 10.1007/s11033-020-05464-w
pii: 10.1007/s11033-020-05464-w
doi:
Substances chimiques
Naphthoquinones
0
Reactive Oxygen Species
0
Gefitinib
S65743JHBS
plumbagin
YAS4TBQ4OQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4155-4168Subventions
Organisme : Department of Science and technology, Science and Engineering Research Board (DST, SERB), New Delhi, India
ID : ECR/2016/000792
Organisme : Department of Science and Technology, Odisha, India
ID : 1201
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