Acute on chronic kidney disease in cats: Etiology, clinical and clinicopathologic findings, prognostic markers, and outcome.
Acute Kidney Injury
/ blood
Animals
Cat Diseases
/ blood
Cats
Creatinine
/ blood
Female
Hospitalization
/ statistics & numerical data
Ischemia
Kidney
/ blood supply
Male
Phosphorus
/ blood
Prognosis
Protons
Pyelonephritis
/ veterinary
Renal Insufficiency, Chronic
/ blood
Retrospective Studies
Urea
/ blood
Ureteral Obstruction
/ veterinary
acute kidney injury
azotemia
renal failure
survival
uremia
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
19
12
2019
revised:
29
04
2020
accepted:
06
05
2020
pubmed:
24
5
2020
medline:
11
3
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) and acute decompensation of CKD (ACKD) are common in cats. To characterize the etiology, clinical and clinicopathologic findings, and the short- and long-term prognosis of feline ACKD. One hundred cats with ACKD. Retrospective study, search of medical records for cats with ACKD. Common clinical signs included anorexia (85%), lethargy (60%), weight loss (39%), and vomiting (27%). Suspected etiologies included ureteral obstruction (11%), renal ischemia (9%), pyelonephritis (8%), others (6%), or unknown (66%). Hospitalization duration was longer in survivors versus nonsurvivors (median = 7 days, range = 2-26 versus median = 3 days, range = 2-20, respectively, P < .001). The survival rate to discharge was 58%. Age, serum creatinine, urea, and phosphorous concentrations were higher and venous blood pH was lower in nonsurvivors. However, only serum phosphorus remained associated with the short-term outcome in the multivariable model (P = .02; 95% confidence interval = 1.03-1.39). Survivors had a median survival time of 66 days after discharge. Serum creatinine concentrations at presentation as well as at discharge were associated with long-term survival (P < .002 for both). The short-term prognosis of ACKD is comparable to acute kidney injury, while the long-term prognosis is guarded.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic kidney disease (CKD) and acute decompensation of CKD (ACKD) are common in cats.
OBJECTIVES
OBJECTIVE
To characterize the etiology, clinical and clinicopathologic findings, and the short- and long-term prognosis of feline ACKD.
ANIMALS
METHODS
One hundred cats with ACKD.
METHODS
METHODS
Retrospective study, search of medical records for cats with ACKD.
RESULTS
RESULTS
Common clinical signs included anorexia (85%), lethargy (60%), weight loss (39%), and vomiting (27%). Suspected etiologies included ureteral obstruction (11%), renal ischemia (9%), pyelonephritis (8%), others (6%), or unknown (66%). Hospitalization duration was longer in survivors versus nonsurvivors (median = 7 days, range = 2-26 versus median = 3 days, range = 2-20, respectively, P < .001). The survival rate to discharge was 58%. Age, serum creatinine, urea, and phosphorous concentrations were higher and venous blood pH was lower in nonsurvivors. However, only serum phosphorus remained associated with the short-term outcome in the multivariable model (P = .02; 95% confidence interval = 1.03-1.39). Survivors had a median survival time of 66 days after discharge. Serum creatinine concentrations at presentation as well as at discharge were associated with long-term survival (P < .002 for both).
CONCLUSIONS
CONCLUSIONS
The short-term prognosis of ACKD is comparable to acute kidney injury, while the long-term prognosis is guarded.
Identifiants
pubmed: 32445217
doi: 10.1111/jvim.15808
pmc: PMC7379052
doi:
Substances chimiques
Protons
0
Phosphorus
27YLU75U4W
Urea
8W8T17847W
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1496-1506Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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