High-speed X-ray-induced luminescence computed tomography.
X-ray
XLCT
computed tomography
luminescence
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
26
02
2020
revised:
18
05
2020
accepted:
19
05
2020
pubmed:
24
5
2020
medline:
24
6
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
X-ray-induced luminescence computed tomography (XLCT) is an emerging molecular imaging. Challenges in improving spatial resolution and reducing the scan time in a whole-body field of view (FOV) still remain for practical in vivo applications. In this study, we present a novel XLCT technique capable of obtaining three-dimensional (3D) images from a single snapshot. Specifically, a customed two-planar-mirror component is integrated into a cone beam XLCT imaging system to obtain multiple optical views of an object simultaneously. Furthermore, a compressive sensing based algorithm is adopted to improve the efficiency of 3D XLCT image reconstruction. Numerical simulations and experiments were conducted to validate the single snapshot X-ray-induced luminescence computed tomography (SS-XLCT). The results show that the 3D distribution of the nanophosphor targets can be visualized much faster than conventional cone beam XLCT imaging method that was used in our comparisons while maintaining comparable spatial resolution as in conventional XLCT imaging. SS-XLCT has the potential to harness the power of XLCT for rapid whole-body in vivo molecular imaging of small animals.
Identifiants
pubmed: 32445254
doi: 10.1002/jbio.202000066
pmc: PMC7598839
mid: NIHMS1637580
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202000066Subventions
Organisme : NCI NIH HHS
ID : R01 CA223667
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227713
Pays : United States
Organisme : NCI NIH HHS
ID : 1R01CA223667; 1R01CA227713
Pays : United States
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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