Erythema multiforme-like lesions in children and COVID-19.
COVID-19
SARS-CoV-2
chilblains
erythema multiforme
exanthem
pernio
skin
viral diseases
Journal
Pediatric dermatology
ISSN: 1525-1470
Titre abrégé: Pediatr Dermatol
Pays: United States
ID NLM: 8406799
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
pubmed:
24
5
2020
medline:
11
7
2020
entrez:
24
5
2020
Statut:
ppublish
Résumé
During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS-CoV-2, while the other three were negative. Skin biopsies from two patients showed features not typical of EM, such as deep perivascular and perieccrine infiltrate and absence of necrosis of keratinocytes. Immunohistochemistry for SARS-CoV/SARS-CoV-2 spike protein showed granular positivity in endothelial cells and epithelial cells of eccrine glands in both biopsies. All patients had an excellent outcome, and had minimal or no systemic symptoms. The coincidence of EM, a condition commonly related to viruses, and chilblains in the setting of COVID-19, and the positivity for SARS-CoV/SARS-CoV-2 spike protein by immunohistochemistry strongly suggest a link between EM-like lesions and SARS-CoV-2.
Identifiants
pubmed: 32445583
doi: 10.1111/pde.14246
pmc: PMC7283638
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
442-446Informations de copyright
© 2020 Wiley Periodicals LLC.
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